Comparison of different endophthalmitis prophylactic measures in cataract surgery - An analysis of 2.4 lakh cases

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dc.contributor.authorReddy, Jagadeesh Kumaren_US
dc.contributor.authorSundaram, Vandhanaen_US
dc.contributor.authorDani, Samruddhien_US
dc.contributor.authorShah, Neerajen_US
dc.contributor.authorIngawale, Ameyaen_US
dc.contributor.authorPooja, C Men_US
dc.date.accessioned2023-08-25T06:35:10Z
dc.date.available2023-08-25T06:35:10Z
dc.date.issued2022-11
dc.description.abstractPurpose: To compare different endophthalmitis prophylaxis methods adopted in cataract surgery (manual small-incision cataract surgery and phacoemulsification) between the years 2013 and 2021 in the community eye care section of a tertiary eye care hospital in South India and report their outcomes. Methods: All cataract surgeries performed from January 2013 to December 2021 (2,46,874 surgeries) at a single center were included in this retrospective study. The different endophthalmitis rates with each regimen were analyzed and evaluated. Results: 70,081 surgeries were performed from January 2013 to February 2015, where Tobramycin was added to Balanced Salt Solution (BSS) (Group A). From March 2015 to January 2017, 63,245 surgeries were performed when intracameral Moxifloxacin was given (Group B). From February 2017 to December 2021, 1,13,548 surgeries were performed were Amikacin was added to BSS (Group C). In total, 42 cases of postoperative endophthalmitis were reported during the study period (0.02%). There was no significant difference in the endophthalmitis rates between groups A and B (P = 0.4152); however, there was a significant decrease in endophthalmitis rates in group C when compared with group A (P = 0.04) and group B (P = 0.006). Conclusion: There was a significant reduction in the rates of endophthalmitis following the addition of amikacin in irrigating BSS. Nocardia was one of the predominant organisms isolated from these endophthalmitis patients. This is the first single-center study to report a comparative analysis of different endophthalmitis prophylactic measures in a community eye care set up with a high incidence of Nocardia endophthalmitis prevented with amikacin in BSS irrigating solution.en_US
dc.identifier.affiliationsDepartment of Cornea and Refractive Surgery, Sankara Eye Hospital Coimbatore, Indiaen_US
dc.identifier.affiliationsDepartment of Cornea and Refractive Surgery, Sankara Eye Hospital, Jaipur, Indiaen_US
dc.identifier.affiliationsConsultant, I Clinic, Mumbai, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, St John抯 Hospital, Bengaluru, Karnataka, Indiaen_US
dc.identifier.citationReddy Jagadeesh Kumar, Sundaram Vandhana, Dani Samruddhi, Shah Neeraj, Ingawale Ameya, Pooja C M. Comparison of different endophthalmitis prophylactic measures in cataract surgery - An analysis of 2.4 lakh cases. Indian Journal of Ophthalmology. 2022 Nov; 70(11): 4000-4002en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224690
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber11en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1596_22en_US
dc.subjectAmikacinen_US
dc.subjectendophthalmitisen_US
dc.subjectmanual small-incision cataract surgeryen_US
dc.subjectmoxifloxacinen_US
dc.titleComparison of different endophthalmitis prophylactic measures in cataract surgery - An analysis of 2.4 lakh casesen_US
dc.typeJournal Articleen_US
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