Outcome of Concurrent Chemoradiation in Inoperable Muscle Invasive Urothelial Carcinoma of Urinary Bladder in terms of Locoregional Response and Toxicities — A Longitudinal Study in a Tertiary Care Hospital

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dc.contributor.authorDas, Sarmilaen_US
dc.contributor.authorChakrabarti, Amitabhaen_US
dc.contributor.authorGhosh, Sourav Kumaren_US
dc.date.accessioned2023-06-17T08:34:11Z
dc.date.available2023-06-17T08:34:11Z
dc.date.issued2022-06
dc.description.abstractBackground : The presenting study was performed to assess the efficacy in terms of tumour response and toxicity profile of a curative intent organ preservation approach in Inoperable Non-metastatic Muscle-Invasive Urinary Bladder Carcinoma. Materials and Methods : Prospective Interventional Single-Arm, Single Center study with a duration of one and half year in which 47 patients with Muscle-invaded Bladder Cancer were treated with Radiotherapy with 64 Gy in 32# along with Concurrent Chemotherapy with three weekly injection Cisplatin in dose of 70 mg/m2. Response evaluation was done using both Clinical and Radiological means and categorized using Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. For adverse events measurement: NCI CTCAE (Common Terminology Criteria for Adverse Events, v4.1) and RTOG/EORTC Acute and Late Morbidity criteria was used. Results : Of the 47 patients who completed chemoradiation, complete treatment response was seen in 25 patients (53.2%), 17 patients (36.2%) had partial response on initial assessment and one patient had disease progression both in form of locoregional and distant (lung) metastasis. Stable disease found in (8.5%). Patients with residual disease were advised to undergo salvage treatment. Grade 3 Nephrotoxicity reported in one patient, Grade 2 Cystitis in 32 patients (68.1%), while Grade 2 Diarrhoea occurred in four patients (8.5%). Hematological toxicity attributable to Chemoradiotherapy included Grade 2, Grade 3 Neutropenia seen in 6.4% and 2.1% respectively and Grade 2 Anaemia in 4.3% patients. Conclusion : Concurrent Chemoradiotherapy is well-tolerated, effective and convenient curative treatment option for patients with Inoperable Non-metastatic Muscle Invasive Carcinoma of Urinary Bladderen_US
dc.identifier.affiliationsDepartment of Radiotherapy, R G Kar Medical College and Hospital, Kolkata 700004en_US
dc.identifier.affiliationsMBBS, Final Year Postgraduate Trainee (MOTR) and Corresponding Authoren_US
dc.identifier.affiliationsMBBS, MD (Radiotherapy), Associate Professoren_US
dc.identifier.affiliationsMBBS, MD (Radiotherapy), Clinical Tutoren_US
dc.identifier.citationDas Sarmila, Chakrabarti Amitabha, Ghosh Sourav Kumar. Outcome of Concurrent Chemoradiation in Inoperable Muscle Invasive Urothelial Carcinoma of Urinary Bladder in terms of Locoregional Response and Toxicities — A Longitudinal Study in a Tertiary Care Hospital. Journal of The Indian Medical Association. 2022 Jun; 120(6): 23-28en_US
dc.identifier.issn0019-5847
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216562
dc.languageenen_US
dc.publisherIndian Medical Associationen_US
dc.relation.issuenumber6en_US
dc.relation.volume120en_US
dc.source.urihttps://www.onlinejima.com/read_journals.php?article=958en_US
dc.subjectUrinary Bladder Urothelial Carcinomaen_US
dc.subjectChemoradiationen_US
dc.subjectToxicitiesen_US
dc.subjectLocal controlen_US
dc.titleOutcome of Concurrent Chemoradiation in Inoperable Muscle Invasive Urothelial Carcinoma of Urinary Bladder in terms of Locoregional Response and Toxicities — A Longitudinal Study in a Tertiary Care Hospitalen_US
dc.typeJournal Articleen_US
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