Cytochrome P450 enzyme isoforms and their therapeutic implications: an update.

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dc.contributor.authorKalra, Bhupinder Singhen_US
dc.date.accessioned2007-02-30en_US
dc.date.accessioned2009-05-29T06:25:58Z
dc.date.available2007-02-30en_US
dc.date.available2009-05-29T06:25:58Z
dc.date.issued2007-02-30en_US
dc.description46 references.en_US
dc.description.abstractClinicians should be cognizant of potential drug drug interactions and become familiar with the substrates, inhibitors and inducers of the common enzymatic pathways responsible for drug metabolism. Our knowledge of and ability to predict drug interactions have improved with growing understanding of substrates, inhibitors and inducers of cytochrome P450 (CYP-450) isoenzymes. These isoenzymes are a major determinant of the pharmacokinetic behavior of numerous drugs. In addition to inhibition and induction, microsomal drug metabolism is affected by genetic polymorphisms, age, nutrition, hepatic disease and endogenous chemicals. Prescribing physicians by understanding the unique characteristics of these isoenzymes may better anticipate and manage drug drug interactions.en_US
dc.description.affiliationDepartment of Pharmacology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi - 110 002, India. drbskalra@gmail.comen_US
dc.identifier.citationKalra BS. Cytochrome P450 enzyme isoforms and their therapeutic implications: an update. Indian Journal of Medical Sciences. 2007 Feb; 61(2): 102-16en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/68802
dc.language.isoengen_US
dc.source.urihttps://www.indianjmedsci.orgen_US
dc.subject.meshCytochrome P-450 Enzyme System --geneticsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEnzyme Inductionen_US
dc.subject.meshEnzyme Inhibitorsen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoenzymesen_US
dc.subject.meshMicrosomes --metabolismen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.titleCytochrome P450 enzyme isoforms and their therapeutic implications: an update.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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