Significance of blood coagulation and platelet profiles in relation to pulmonary thrombosis in beta-thalassemia/Hb E.

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dc.contributor.authorVisudhiphan, Sen_US
dc.contributor.authorKetsa-Ard, Ken_US
dc.contributor.authorTumliang, Sen_US
dc.contributor.authorPiankijagum, Aen_US
dc.date.accessioned2009-05-27T16:13:16Z
dc.date.available2009-05-27T16:13:16Z
dc.date.issued1994-09-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractIn beta-Thalassemia hemoglobin E (beta-thal Hb E), hypoxemia with abnormal lung function was described and postmortem examination in these patients showed organized pulmonary trombi with thickened arterial wall, particularly in post-splenectomized cases. Coagulation and platelet profiles were studied in 58 beta-thal Hb E patients. In 35 cases with intact spleen, the fibrinolytic activity was significantly decreased with high antithrombin III activity, while coagulation tests revealed mild abnormality. The platelet aggregation to ADP, adrenaline, collagen and ristocretin were defective and platelet 5-hydroxytryptamine content was lower than normal. Twenty-three patients who had been splenectomized for 5-18 years, decreased fibrinolytic activity and high antithrombin III activity were also observed. The coagulation profiles and platelet aggregation in response to ADP, adrenaline and collagen showed better results. Fourteen cases exhibited thrombocytosis and their thrombin generation was in the hypercoagulable range. Platelet aggregation in response to ristocetin remained defective and platelet 5-hydroxytryptamine content was lower than in cases with intact spleens. Defective aggregation to ristocetin would indicate abnormal von Willebrand's factor (vWF). Decreased fibrinolysis should very likely have a role in the occurrence of thrombosis and the better hemostatic profiles in post-splenectomized cases would contribute to the more frequent thrombotic incidence in these cases.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationVisudhiphan S, Ketsa-Ard K, Tumliang S, Piankijagum A. Significance of blood coagulation and platelet profiles in relation to pulmonary thrombosis in beta-thalassemia/Hb E. The Southeast Asian Journal of Tropical Medicine and Public Health. 1994 Sep; 25(3): 449-56en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34704
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAntithrombin III --metabolismen_US
dc.subject.meshBlood Coagulationen_US
dc.subject.meshBlood Platelets --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinolysisen_US
dc.subject.meshHemoglobin Een_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPlatelet Aggregationen_US
dc.subject.meshPlatelet Counten_US
dc.subject.meshPulmonary Embolism --etiologyen_US
dc.subject.meshSerotonin --blooden_US
dc.subject.meshSplenectomyen_US
dc.subject.meshbeta-Thalassemia --blooden_US
dc.titleSignificance of blood coagulation and platelet profiles in relation to pulmonary thrombosis in beta-thalassemia/Hb E.en_US
dc.typeJournal Articleen_US
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