Histopathological evaluation of endometrial glycogen deficiency in primary and secondary infertile women in Bangladesh: a cross-sectional study

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dc.contributor.authorYasmin, Ren_US
dc.contributor.authorRahman, Fen_US
dc.contributor.authorAfroz, Sen_US
dc.contributor.authorHaque, SMen_US
dc.contributor.authorIslam, Sen_US
dc.contributor.authorFaruque, N.en_US
dc.date.accessioned2025-06-18T11:13:46Z
dc.date.available2025-06-18T11:13:46Z
dc.date.issued2025-06
dc.description.abstractBackground: Infertility is a major public health issue, affecting a significant proportion of couples worldwide. Endometrial receptivity, influenced by glycogen content, plays a crucial role for successful implantation. This study aimed to evaluate the glycogen content and histomorphological patterns of the endometrium in infertile women in Bangladesh, focusing on differences between primary and secondary infertility. Methods: This cross-sectional observational study was conducted at BIRDEM General Hospital, Dhaka, from July 2019 to June 2021. A total of 110 endometrial samples from infertile women from both primary and secondary infertility were analyzed. Samples were collected during the secretory phase of the menstrual cycle and assessed by using Hematoxylin and Eosin (H&E) and Periodic Acid Schiff (PAS) staining. Glycogen content was graded on a scale from �to �++++� and analyzed across different types of infertility and histomorphological patterns. Results: The majority of participants were aged 26-30 years (43.64%), with primary infertility being more prevalent (63.64%) than secondary infertility (36.36%). Deficient glycogen content was observed in 71.43% of primary infertility cases, compared to 60.00% of secondary infertility cases. Normal glycogen levels were more frequent in the secretory phase, particularly the late secretory phase, with 36 cases showing �+++� and 5 cases showing �++++� grades. Variations in glycogen content were also noted across histomorphological patterns, with Luteal Phase Defect (LPD) cases displaying mixed glycogen levels. Conclusion: The study underscores the importance of adequate glycogen content in endometrial receptivity and its association with infertility. The findings suggest that histopathological evaluation of glycogen levels, particularly using PAS staining, can be an effective diagnostic tool for assessing endometrial health in infertile women. Addressing glycogen deficiencies may improve reproductive outcomes, and further research is needed to understand the underlying mechanisms contributing to variability in glycogen content.en_US
dc.identifier.affiliationsDepartment of Pathology, Dhaka Central International Medical College, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pathology, Shaheed Monsur Ali Medical College, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Histopathology, National Institute of Cancer Research and Hospital, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pathology, Shaheed Monsur Ali Medical College, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Kumudini Women抯 Medical College and Hospital, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Chemistry, Dhaka University, Dhaka, Bangladeshen_US
dc.identifier.citationYasmin R, Rahman F, Afroz S, Haque SM, Islam S, Faruque N.. Histopathological evaluation of endometrial glycogen deficiency in primary and secondary infertile women in Bangladesh: a cross-sectional study. International Journal of Advances in Medicine. 2025 Jun; 12(3): 271-277en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/248355
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2349-3933.ijam20251075en_US
dc.subjectInfertilityen_US
dc.subjectEndometrial glycogenen_US
dc.subjectHistomorphologyen_US
dc.subjectLuteal phase defecten_US
dc.subjectPAS Stainingen_US
dc.subjectPrimary infertilityen_US
dc.subjectSecondary infertilityen_US
dc.titleHistopathological evaluation of endometrial glycogen deficiency in primary and secondary infertile women in Bangladesh: a cross-sectional studyen_US
dc.typeJournal Articleen_US
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