Nano-curcumin ameliorates arsenic induced hepatotoxicity in female rats

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dc.contributor.authorVashistha, L.M.en_US
dc.contributor.authorSingh, M.en_US
dc.contributor.authorVerma, Y.en_US
dc.contributor.authorRana, S.V.S.en_US
dc.date.accessioned2024-11-30T11:59:23Z
dc.date.available2024-11-30T11:59:23Z
dc.date.issued2023-11
dc.description.abstractAim: To determine the protective effects of curcumin and nanocurcumin against arsenic-induced hepatotoxicity in female rats, using liver function tests and oxidative stress parameters. Methodology: Arsenic trioxide (4 mg kg-1 b.wt.), curcumin and nano curcumin (50 mg kg-1 b.wt.) were administered to healthy rats as a chronic treatment for 60 days through gavage. The liver tissue samples of exposed rats were examined for histopathological alterations, liver function tests viz. alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin (BIL) and a lipid peroxidation product-malonaldehyde (MDA). Results: Treatments with both forms of curcumin could significantly (p 0<0.05) improve liver function as indicated by serum enzyme biomarkers viz. AST, ALT, ALP and LDH. Hyper-bilirubinemia was also diminished. Fibro-proliferation caused by arsenic in the liver was also controlled by curcumin (s). Histopathological observations of liver showed significant improvement in its morphology post treatments. Interpretation: Present results suggest that curcumin and nanocurcumin both express hepatoprotective effects in arsenic treated rats. However, nanocurcumin was found to offer better protection than curcumin.en_US
dc.identifier.affiliationsDepartment of Toxicology, Chaudhary Charan Singh University, Meerut-250 004, Indiaen_US
dc.identifier.affiliationsDepartment of Toxicology, Chaudhary Charan Singh University, Meerut-250 004, Indiaen_US
dc.identifier.affiliationsDepartment of Toxicology, Chaudhary Charan Singh University, Meerut-250 004, Indiaen_US
dc.identifier.affiliationsDepartment of Toxicology, Chaudhary Charan Singh University, Meerut-250 004, Indiaen_US
dc.identifier.citationVashistha L.M., Singh M., Verma Y., Rana S.V.S.. Nano-curcumin ameliorates arsenic induced hepatotoxicity in female rats. Journal of Environmental Biology. 2023 Nov; 44(6): 775-783en_US
dc.identifier.issn0254-8704
dc.identifier.issn2394-0379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/238476
dc.languageenen_US
dc.publisherTriveni Enterprisesen_US
dc.relation.issuenumber6en_US
dc.relation.volume44en_US
dc.source.urihttps://doi.org/10.22438/jeb/44/6/5138en_US
dc.subjectArseniasisen_US
dc.subjectFibrosisen_US
dc.subjectLipid peroxidationen_US
dc.subjectLiver functionen_US
dc.subjectNanocurcuminen_US
dc.titleNano-curcumin ameliorates arsenic induced hepatotoxicity in female ratsen_US
dc.typeJournal Articleen_US
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