Clinical, biochemical and haematological changes in leptospirosis

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dc.contributor.authorModi, Rahul A.en_US
dc.contributor.authorPatel, Ankita K.en_US
dc.contributor.authorPatel, Mubin I.en_US
dc.contributor.authorPadsala, Suresh G.en_US
dc.date.accessioned2020-11-18T09:57:29Z
dc.date.available2020-11-18T09:57:29Z
dc.date.issued2019-01
dc.description.abstractBackground: Leptospirosis is a globally important zoonotic disease caused by pathogenic leptospira. Leptospira species are spirochetes belonging to the order spirochetes and the family leptospiraceae. Present study is done to find out the incidence of thrombocytopenia in leptospirosis and to correlate it with other parameters like renal dysfunction, hepatic dysfunction and bleeding manifestation.Methods: Study includes 51 clinically suspected and diagnosed cases of leptospirosis, in Government hospital, South Gujarat, during a period from January 2017 to December 2017. Clinical signs and symptoms and complications, biochemical profile like bilirubin and creatinine, haematological profile like Hb, WBC count and platelet count were recorded. Thrombocytopenia was defined as a platelet count below 1,50,000/cmm.Results: The present study includes 51 cases of Leptospirosis. Age ranged from 16 years to 61 years (male-39 and Females-12) There were 38 (74.5%) cases with thrombocytopenia and 13 (25.4%) cases with normal platelet count. Out of 38 thrombocytopenic cases, 32 (84.2%) cases had renal dysfunction, 26 (68.4%) cases had hepatic dysfunction and 16 (42.1%) cases had pulmonary haemorrhage. Among 13 cases with normal platelet count, 8 (61.5%) cases had hepatic dysfunction and 7 (53.8%) cases had renal dysfunction and 3 (23%) cases had pulmonary haemorrhage.Conclusions: Thrombocytopenia is a frequent complication (present in more than half of the patient) in leptospirosis and associated with more frequent and more severe complications. Therefore, early recognition of thrombocytopenia is recommended to prevent complications and mortality in leptospirosis.en_US
dc.identifier.affiliationsDepartment of Pathology, Government Medical College, Surat, Gujarat, Indiaen_US
dc.identifier.citationModi Rahul A., Patel Ankita K., Patel Mubin I., Padsala Suresh G.. Clinical, biochemical and haematological changes in leptospirosis. International Journal of Research in Medical Sciences. 2019 Jan; 7(1): 205-208en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211093
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20185381en_US
dc.subjectComplicationsen_US
dc.subjectLeptospirosisen_US
dc.subjectThrombocytopeniaen_US
dc.titleClinical, biochemical and haematological changes in leptospirosisen_US
dc.typeJournal Articleen_US
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