Amniotic membrane transplantation: a review of current indications in the management of ophthalmic disorders.

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dc.contributor.authorSangwan, Virender Sen_US
dc.contributor.authorBurman, Sanghamitraen_US
dc.contributor.authorTejwani, Sushmaen_US
dc.contributor.authorMahesh, Sankaranarayana Pillaien_US
dc.contributor.authorMurthy, Rameshen_US
dc.date.accessioned2007-07-28en_US
dc.date.accessioned2009-05-29T09:08:33Z
dc.date.available2007-07-28en_US
dc.date.available2009-05-29T09:08:33Z
dc.date.issued2007-07-28en_US
dc.description78 references.en_US
dc.description.abstractAmniotic membrane transplantation is currently being used for a continuously widening spectrum of ophthalmic indications. It has gained widespread attention as an effective method of reconstruction of the ocular surface. Amniotic membrane has a unique combination of properties, including the facilitation of migration of epithelial cells, the reinforcement of basal cellular adhesion and the encouragement of epithelial differentiation. Its ability to modulate stromal scarring and its anti-inflammatory activity has led to its use in the treatment of ocular surface pathology as well as an adjunct to limbal stem cell grafts. Amniotic membrane transplantation has been used for reconstruction of the corneal surface in the setting of persistent epithelial defects, partial limbal stem cell deficiency, bullous keratopathy and corneoscleral ulcers. It has also been used in conjunction with limbal stem cell transplantation for total limbal stem cell deficiency. Amniotic membrane grafts have been effectively used as a conjunctival substitute for reconstruction of conjunctival defects following removal of pterygia, conjunctival lesions and symblephara. More recently, amniotic membrane has been used as a substrate for ex vivo cultivation of limbal, corneal and conjunctival epithelial cells. This article reviews the current literature on the applications of amniotic membrane transplantation and its outcome in various ophthalmic conditions.en_US
dc.description.affiliationCornea and Anterior Segment Services, LV Prasad Eye Institute, Banjara Hills, Hyderabad, India. vsangwan@lvpei.orgen_US
dc.identifier.citationSangwan VS, Burman S, Tejwani S, Mahesh SP, Murthy R. Amniotic membrane transplantation: a review of current indications in the management of ophthalmic disorders. Indian Journal of Ophthalmology. 2007 Jul-Aug; 55(4): 251-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/71265
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshAmnion --transplantationen_US
dc.subject.meshEye Diseases --surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleAmniotic membrane transplantation: a review of current indications in the management of ophthalmic disorders.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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