Randomized controlled trial on the effective dose of anti-snake venom in cases of snake bite with systemic envenomation.

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dc.contributor.authorTariang, D Den_US
dc.contributor.authorPhilip, P Jen_US
dc.contributor.authorAlexander, Gen_US
dc.contributor.authorMacaden, Sen_US
dc.contributor.authorJeyaseelan, Len_US
dc.contributor.authorPeter, J Ven_US
dc.contributor.authorCherian, A Men_US
dc.date.accessioned1999-04-25en_US
dc.date.accessioned2009-05-30T19:40:41Z
dc.date.available1999-04-25en_US
dc.date.available2009-05-30T19:40:41Z
dc.date.issued1999-04-25en_US
dc.description.abstractSnake bite is the common cause of morbidity and mortality in India. Snake antivenom, although very effective, is expensive, scarce, and associated with side effects. The conventional dose may not be required in all cases and a smaller dose may be as effective. A randomized double blind controlled trial was conducted to compare the effect of lower versus the conventional (high) dose. Patients presenting within 24 hours of snake bite with hematological or neurological evidence of systemic envenomation were included in the study. Patients were randomized either to receive high dose (2 vials over 1 hour, followed by 2 vials over 4 hours and repeated 4 hourly until clotting parameters normalized and then 2 vials as infusion over 24 hours) or low dose (2 vials over 1 hour, followed by 1 vial over four hours, repeated 4 hourly until clotting parameters were normalized and then 1 vial as an infusion over 24 hours). Thirty one patients received high dose and 29 a low dose. The mean dose of antivenom used was significantly different in the two groups (8.9 and 4.7, respectively). There was no mortality. The duration of stay was 4.94 and 3.48 days, respectively. There was no difference in the transfusion, dialysis or ventilation requirement of the two groups. Low dose regimen is more effective and required 5 vials less than the conventional dose. Each vial costs Rs. 200, so the estimated savings is Rs. 1000 per patient.en_US
dc.description.affiliationDept of Medicine, Bangalore Baptist Hospital.en_US
dc.identifier.citationTariang DD, Philip PJ, Alexander G, Macaden S, Jeyaseelan L, Peter JV, Cherian AM. Randomized controlled trial on the effective dose of anti-snake venom in cases of snake bite with systemic envenomation. Journal of the Association of Physicians of India. 1999 Apr; 47(4): 369-71en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/86996
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAntivenins --administration & dosageen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshSnake Bites --mortalityen_US
dc.titleRandomized controlled trial on the effective dose of anti-snake venom in cases of snake bite with systemic envenomation.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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