A study of histopathological features of medullary carcinoma of the thyroid: cases from a single institute in India.

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dc.contributor.authorDesai, Saral Sen_US
dc.contributor.authorSarkar, Suchanaen_US
dc.contributor.authorBorges, Anita Men_US
dc.date.accessioned2009-05-28T06:37:07Z
dc.date.available2009-05-28T06:37:07Z
dc.date.issued2005-01-05en_US
dc.description.abstractBACKGROUND: The microscopic features of medullary carcinoma have been described in world literature, together with its behavior and molecular biology. However, no large study has been reported from India. AIMS: This study aims to analyse the clinical, and especially the pathological features of medullary carcinoma of the thyroid, and the surrounding thyroid. MATERIALS AND METHODS: In this study a total of 234 cases of medullary thyroid carcinoma (MTC) were gathered over a period of 3 decades. The clinical presentation, the microscopic features and the clinical outcome were analyzed. RESULTS: MTC was found to be twice as common in men as in women and for some reason it occurred 10 years earlier in women. The histology revealed certain interesting features like the presence of apoptosis in over half of the tumors, in addition to the other common and not so common histological findings (encapsulated variant, small cell variants, follicular pattern, rosettes, oncocytic change, osteosarcoma-like pattern, and cribriform pattern). The adjacent thyroid in about 19% of the cases showed optically clear nuclei in the follicles that were close to the tumor cells. These features were similar to those seen in papillary thyroid carcinoma. CONCLUSIONS: The thyroid adjacent to MTC showed nuclear changes, which are also found in papillary carcinoma of the thyroid. The occasional concurrent occurrence of these two tumors and the involvement of the RET gene in both medullary and papillary carcinomas, makes this observation worth discussing and studying further.en_US
dc.description.affiliationDepartment of Pathology, Tata Memorial Hospital, Dr. Ernest Borges Road, Parel, Mumbai 400012, India. saraldesai@hotmail.comen_US
dc.identifier.citationDesai SS, Sarkar S, Borges AM. A study of histopathological features of medullary carcinoma of the thyroid: cases from a single institute in India. Indian Journal of Cancer. 2005 Jan-Mar; 42(1): 25-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/50117
dc.language.isoengen_US
dc.source.urihttps://www.indianjcancer.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Medullary --epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMedical Recordsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshThyroid Neoplasms --epidemiologyen_US
dc.titleA study of histopathological features of medullary carcinoma of the thyroid: cases from a single institute in India.en_US
dc.typeJournal Articleen_US
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