Insulin-like growth factors and their binding proteins in children with IDDM.

Simple item page
dc.contributor.authorWacharasindhu, Suttipongen_US
dc.contributor.authorSrivuthana, Sumarleeen_US
dc.contributor.authorAroonparkmongkol, Suphaben_US
dc.date.accessioned2009-05-27T20:56:16Z
dc.date.available2009-05-27T20:56:16Z
dc.date.issued2002-01-22en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThe structure of insulin-like growth factor (IGF), especially IGF-I, and its receptor is similar to that of insulin. Therefore, the changes of IGFs and IGF-binding proteins may be related to glucose homeostasis in children with insulin dependent diabetes mellitus (IDDM). Sixty-three fasting blood samples of 21 children with IDDM attending 3 consecutive diabetic clinics were studied. The HbA1c progressively decreased from the 1st to the 3rd visit. IGF-I levels, both total and free forms, were not significantly different from that of control. IGFBP-3 levels in 3 visits (3406+/-305, 3376+/-252, and 2406+/-247 ng/mL) were significantly lower than that of control (5020+/-415 ng/mL) with the p value of 0.007, 0.002, and < 0.001 respectively. IGFBP-1 levels in the 1st and 2nd visits (102.1+/-12.9 and 114.1+/-14.5 ng/mL) were significantly higher than that of control (60.1+/-15.2 ng/mL) with the p value of 0.03 and 0.01 respectively, but not in the 3rd visit. IGF-I level had a positive correlation with IGFBP-3 (R=0.56, p=0.01) and free IGF-I (R=0.53, p=0.01). Free IGF-I had a negative correlation with IGFBP-1 (R=-0.64, p=0.01). IGF-II at the 15 visit had a negative correlation with HbA1c (R=-0.49, p=0.047). The authors found no correlations between IGF-I, IGFBP-3, free IGF-I, IGFBP-1 and HbA1c in the study. The patients' height SDS followed the genetic height potential. It was, therefore, postulated that a near normal free IGF-I level in diabetic children resulted from a balance of interaction between IGFBP-1 and IGFBP-3 to total IGF-I in order to keep the normal metabolic status as much as possible.en_US
dc.description.affiliationDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationWacharasindhu S, Srivuthana S, Aroonparkmongkol S. Insulin-like growth factors and their binding proteins in children with IDDM. Journal of the Medical Association of Thailand. 2002 Jan; 85(1): 41-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/43903
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshBlood Glucose --metabolismen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDiabetes Mellitus, Type 1 --blooden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-Like Growth Factor Binding Protein 1 --analysisen_US
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3 --analysisen_US
dc.subject.meshInsulin-Like Growth Factor Binding Proteins --blooden_US
dc.subject.meshInsulin-Like Growth Factor I --analysisen_US
dc.subject.meshInsulin-Like Growth Factor II --analysisen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshProbabilityen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshSomatomedins --analysisen_US
dc.titleInsulin-like growth factors and their binding proteins in children with IDDM.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Medical Association of Thailand