Is there any diagnostic value of serum caveolin-1 levels on the determination of pancreatic adenocarcinoma?
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Date
2024-12
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Publisher
Wolters Kluwer – Medknow
Abstract
Background: Caveolin‑1 (CAV‑1) is a vital component in cancer pathogenesis, as its expression determines the survival of patients with cancer. This study investigates CAV‑1 serum levels in pancreatic adenocarcinoma (PA) patients and their role in tumor progression and prognostic factors. Method: The trial included 33 patients with pathologically confirmed pancreatic cancer (PC). The enzyme‑linked immunosorbent assay (ELISA) method was used to measure the concentrations of CAV‑1 in the blood. The study also included 20 healthy subjects. The statistical analysis was two‑sided, and a P value of ≤ 0.05 was determined as statistically significant. Results: The median age of the subjects was 59 years (32–84 years) at the time of diagnosis. There were 13 (39%) female participants. In 21 (63%) patients, the primary focus was the pancreatic head. In 23 stage IV patients, hepatic metastasis (n = 19, 83%) was observed. Only one patient (3%) was still alive at the end of the study period. Palliative chemotherapy (CTx) was provided, with 39% of the 23 patients responding to it. The overall survival (OS) rate in this cohort was 41.3 ± 8.3 weeks at a 95% confidence interval (CI), after 25–58 weeks. Serum baseline CAV‑1 values among patients with PA were significantly higher compared with controls (p = 0.009). Patients with poor performance status, a pancreatic head tumor, lower albumin levels, higher serum carcinoembryonic antigen (CEA) levels, and higher CA 19.9 levels had significantly higher serum CAV‑1 levels (p = 0.01, P = 0.05, P = 0.03, P = 0.02, and P = 0.04, respectively). However, CAV‑1 did not show any prognostic value (p = 0.75). Conclusion: Although serum CAV‑1 is a useful diagnostic marker in PC patients, it is not a prognostic or predictive marker.
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Keywords
Caveolin‑1, diagnostic, pancreatic cancer, serum
Citation
Karabulut Senem, Afsar Cigdem U., Paksoy Nail, Ferhatoglu Ferhat, Dogan Izzet, Tastekin Didem. Is there any diagnostic value of serum caveolin-1 levels on the determination of pancreatic adenocarcinoma?. Journal of Cancer Research and Therapeutics. 2024 Dec; 20(6): 1726-1730