Role of serum fibrinogen in patients of ischemic cerebrovascular disease.

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dc.contributor.authorBeg, Mujahiden_US
dc.contributor.authorNizami, Abraaren_US
dc.contributor.authorSinghal, Krishan Chandraen_US
dc.contributor.authorMohammed, Jasimen_US
dc.contributor.authorGupta, Ankushen_US
dc.contributor.authorAzfar, Shah Farhanen_US
dc.date.accessioned2009-05-28T04:15:43Z
dc.date.available2009-05-28T04:15:43Z
dc.date.issued2007-06-29en_US
dc.descriptionNepal Medical College Journal.en_US
dc.description.abstractFibrinogen is an independent risk factor for coronary events in population-based studies and inpatients with coronary heart disease, but there is an uncertainty about its prediction for stroke, particularly in secondary prevention. In view of this uncertainty, study was conducted to establish the role of serum fibrinogen in ischemic stroke. Fifty six patients with acute ischemic stroke of less than 7 days duration were recruited for the study. Fourty two age and sex matched candidates served as control. Baseline characteristics and blood pressure were recorded at admission to hospital. Computer tomography head was done in all patients as per protocol. Sampling took place in the early morning (7-9 AM) using all necessary precaution and serum fibrinogen was measured by method of Clauss. Statiscal analysis was performed using student t test and fisher exact test. In present study, mean plasma fibrinogen in patients group was 326.45 mg/dl, which was significantly higher than control group (202.23 mg/dl) (p<0.001). Mean plasma fibrinogen level in lacunar infarct and non-lacunar infarct did not differ significantly (307.47 mg/dl Vs. 333.19 mg/dl). Smoking was found to be a significant predictor of fibrinogen with 36.7% predictability whereas other parameters (risk factors for ischemic stroke) had little or no predictable value regarding serum fibrinogen. After adjustment for other possible ischemic stroke risk factors; plasma fibrinogen levels was found to be still significantly high in patients as compared to controls (p<0.001). Mean plasma fibrinogen level between patients who survived and who expired does not differ significantly. Present study concluded that fibrinogen is a powerful predictor of ischemic stroke though it does not predict the type and prognosis of stroke.en_US
dc.description.affiliationDepartment of Medicine, J.N. Medical College, AMU, Aligarh, India. mujahidbeg@rediffmail.comen_US
dc.identifier.citationBeg M, Nizami A, Singhal KC, Mohammed J, Gupta A, Azfar SF. Role of serum fibrinogen in patients of ischemic cerebrovascular disease. Nepal Medical College Journal. 2007 Jun; 9(2): 88-92en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/46658
dc.language.isoengen_US
dc.source.urihttps://www.nmcth.edu/list_journal_articles.phpen_US
dc.source.urihttps://www.nmcth.edu/nmcj_articles_pdf/volume_wise/Vol9_No2_June_2007/Mujahid%20Beg.pdfen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshBrain Ischemia --blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinogen --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking --adverse effectsen_US
dc.subject.meshStroke --blooden_US
dc.titleRole of serum fibrinogen in patients of ischemic cerebrovascular disease.en_US
dc.typeJournal Articleen_US
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