Neonatal screening for congenital hypothyroidism using the filter paper thyroxine technique.

Simple item page
dc.contributor.authorDesai, M Pen_US
dc.contributor.authorUpadhye, Pen_US
dc.contributor.authorColaco, M Pen_US
dc.contributor.authorMehre, Men_US
dc.contributor.authorNaik, S Pen_US
dc.contributor.authorVaz, F Een_US
dc.contributor.authorNair, Nen_US
dc.contributor.authorThomas, Men_US
dc.date.accessioned1994-07-01en_US
dc.date.accessioned2009-05-27T08:12:31Z
dc.date.available1994-07-01en_US
dc.date.available2009-05-27T08:12:31Z
dc.date.issued1994-07-01en_US
dc.description.abstractA total of 25,244 full term consecutive newborns were screened for hypothyroidism at 24 to 96 h of birth using the filter paper technique for thyroxine. The screening protocol based on our pilot study considered filter paper thyroxine (FP-T4) values of 51 to 80 ng/ml (-1 SD) as borderline and < 50 ng/ml (-2 SD) as high risk for congenital hypothyroidism. FP-T4 and/or serum T4 and TSH were reestimated in all neonates with FP-T4 < 80 ng/ml. A total of 4775 (18.9%) newborns (FP-T4, 51 to 80 ng/ml in 4435 and < 50 ng/ml in 340) needed the recall; 2237 (50.4%) with FP-T4 51 to 80 ng/ml recalled by letters and 283 (83.3%) of the 340 subjects with FP-T4 < 50 ng/ml recalled by home visit, responded by 6 wk of age. Congenital hypothyroidism was confirmed in 6 newborns. FP-T4 in one persisted at 55 ng/ml on follow up and in the remainder both initial and repeat values were < 50 ng/ml. Follow up serum T4 values were subnormal (7.8-50.2 ng/ml) and serum TSH elevated (80-1233 IU/ml). Technetium thyroid scan showed agenesis in 3, ectopia in 2 and normal gland with probable dyshormonogenesis in one. Three other newborns (FP-T4 93 to 143 ng/ml) escaped primary detection and were referred later for congenital hypothyroidism. The incidence of congenital hypothyroidism by primary screening was 1:4207 (6 of 25,244) but with these 3 missed cases, probably 1:2804. Congenital hypothyroidism was reconfirmed in all 9 infants between the ages of 2 1/2 to 4 yr.(ABSTRACT TRUNCATED AT 250 WORDS)en_US
dc.description.affiliationBai Jerbai Wadia Hospital for Children, Bombay.en_US
dc.identifier.citationDesai MP, Upadhye P, Colaco MP, Mehre M, Naik SP, Vaz FE, Nair N, Thomas M. Neonatal screening for congenital hypothyroidism using the filter paper thyroxine technique. Indian Journal of Medical Research. 1994 Jul; 100(): 36-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23627
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshCongenital Hypothyroidismen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism --diagnosisen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshNeonatal Screening --methodsen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshThyroxine --blooden_US
dc.titleNeonatal screening for congenital hypothyroidism using the filter paper thyroxine technique.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Research