Product stabilization of the two forms of carboxypeptidase A from buffalo pancreas.
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Date
1985-09
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Abstract
The two forms of buffalo carboxypeptidase A lose a part of their activity when
incubated at their optimal temperature. Both the forms are protected from heat denaturation
by L-phenylalanine, one of the reaction products while the other reaction product hippuric
acid provides only limited protection. It has also been shown that L-phenylalanine and
hippuric acid bind at the same site of the enzyme and that the release of L-phenylalanine
follows that of hippuric acid. On this basis, a new mechanism for the hydrolysis of
acyldipeptides by carboxypeptidase A has been proposed.
Description
Keywords
Product L-phenylalanine, stabilization, carboxypeptidase A
Citation
Sud Mir, Dua R D. Product stabilization of the two forms of carboxypeptidase A from buffalo pancreas. Journal of Biosciences. 1985 Sept; 9(1&2): 83-90.