Chemopreventive action of Boerhaavia diffusa on DMBA-induced skin carcinogenesis in mice.

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dc.contributor.authorBharali, Rupjyotien_US
dc.contributor.authorAzad, Mohammed R Hen_US
dc.contributor.authorTabassum, Jawahiraen_US
dc.date.accessioned2003-10-23en_US
dc.date.accessioned2009-06-01T08:00:11Z
dc.date.available2003-10-23en_US
dc.date.available2009-06-01T08:00:11Z
dc.date.issued2003-10-23en_US
dc.description.abstractBoerhaavia diffusa, Linn (Fam: Nyctagenaceae), is widely used for the treatment of Jaundice in various parts of India. In the present study, cancer chemopreventive property of B. diffusa was evaluated on 7,12-dimethyl benz(a)anthracene (DMBA) induced skin papillomagenesis in male Swiss albino mice (6-7 weeks old). A single topical application of 7,12-dimethyl benz(a)anthracene (50 microg/50 microl of acetone), followed 2 weeks later by repeated application of croton oil (1% in acetone three times a week) and continued till the end of the experiment exhibited 100% tumor incidence. In contrast, mice treated topically on the shaven backs with the Boerhaavia diffusa extract at either the peri-initiational phase (i.e. 7 days before and 7 days after the application of DMBA; Group II), post initiational phase (i.e. from the day of start of croton oil treatment and continued till the end of the experiment; Group III) or continuously at the peri- and post-initiational stages (i.e. 7 days prior to DMBA application and continued till the end of the experiment; Group IV), a significant reduction in the values of tumor incidence (Group II - 65%; Group III - 30%; Group IV - 25%), average number of tumors per tumor bearing mouse (Group II - 2.8; Group III - 0.75; Group IV - 0.35) and papillomas per papilloma bearing mouse (Group II - 3.1; Group III - 2.5; Group IV - 1.2) were observed.en_US
dc.description.affiliationDepartment of Biotechnology, Gauhati University, Guwahati 781 014.en_US
dc.identifier.citationBharali R, Azad MR, Tabassum J. Chemopreventive action of Boerhaavia diffusa on DMBA-induced skin carcinogenesis in mice. Indian Journal of Physiology and Pharmacology. 2003 Oct; 47(4): 459-64en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108584
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.mesh9,10-Dimethyl-1,2-benzanthracene --toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshNyctaginaceaeen_US
dc.subject.meshPapilloma --chemically induceden_US
dc.subject.meshPhytotherapy --methodsen_US
dc.subject.meshPlant Extracts --isolation & purificationen_US
dc.subject.meshPlant Leavesen_US
dc.subject.meshPlant Stemsen_US
dc.subject.meshSkin Neoplasms --chemically induceden_US
dc.titleChemopreventive action of Boerhaavia diffusa on DMBA-induced skin carcinogenesis in mice.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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