Correlations between apoptotic and proliferative indices in cervical intraepithelial neoplasia and carcinoma.

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dc.contributor.authorDey, Pen_US
dc.contributor.authorDas, Ren_US
dc.contributor.authorSabuddin,en_US
dc.date.accessioned2000-07-24en_US
dc.date.accessioned2009-05-29T13:42:05Z
dc.date.available2000-07-24en_US
dc.date.available2009-05-29T13:42:05Z
dc.date.issued2000-07-24en_US
dc.description.abstractAims of the present paper was to study cell death by apoptosis and cell proliferation in normal cervical biopsies, cervical intraepithelial neoplasms (CIN) and squamous cell carcinomas of cervix (CaCx). There were each seven cases of normal cervical biopsy, CIN1 and CIN2 along with 10 cases of CIN3 and 14 cases of CaCx. Percentage of apoptotic cells and bodies (i.e. apoptotic index, AI) and mitoses (i.e. mitotic index, MI) and turnover index (TI - AI + MI) were counted in formalin fixed, paraffin embedded, haematoxylin and eosin stained slides. AgNOR stain was done and mean AgNOR dots per cell was also estimated. AI, MI and TI were correlated with histology grade of CIN and invasive carcinoma cervix. Mean AI, MI, TI and AgNOR count increased from lower to higher grades of CIN. AI, MI & TI raised significantly from CIN3 to carcinomas; AI, TI & AgNOR count raised significantly from CIN1 to combined CIM2 & 3; TI & AgNOR count were high in CIN1 to CIN2; AI & TI were significantly raised in normal to CIN1. In conclusion, TI is probably more important for cell kinetic analysis of CIN and carcinoma of cervix because it reflects the frequency of two important events i.e. mitosis and cell death. Sudden increase of AI, MI, TI count from CIN3 to CaCx may indicate the possibility of genetic alteration of cells of CIN3 which induces a frank malignant transformation from CIN3 to CaCx.en_US
dc.description.affiliationAligarh Muslim University, Aligarh.en_US
dc.identifier.citationDey P, Das R, Sabuddin . Correlations between apoptotic and proliferative indices in cervical intraepithelial neoplasia and carcinoma. Indian Journal of Pathology & Microbiology. 2000 Jul; 43(3): 271-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75928
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshApoptosis --physiologyen_US
dc.subject.meshBiopsyen_US
dc.subject.meshCarcinoma, Squamous Cell --pathologyen_US
dc.subject.meshCell Division --physiologyen_US
dc.subject.meshCervical Intraepithelial Neoplasia --pathologyen_US
dc.subject.meshCervix Uteri --pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMitosisen_US
dc.subject.meshUterine Cervical Neoplasms --pathologyen_US
dc.titleCorrelations between apoptotic and proliferative indices in cervical intraepithelial neoplasia and carcinoma.en_US
dc.typeJournal Articleen_US
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