Hormonal contraceptive like effect of estrogen in milk protein-fed male rats.

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dc.contributor.authorBiswas, Narendra Mohanen_US
dc.contributor.authorChattopadhyay, Aloken_US
dc.contributor.authorSarkar, Mahitoshen_US
dc.date.accessioned2009-05-28T04:23:27Z
dc.date.available2009-05-28T04:23:27Z
dc.date.issued2006-06-05en_US
dc.descriptionNepal Medical College Journal.en_US
dc.description.abstractAdult male rats received daily injections (sc) of estradiol-17 beta (50 microg/100 g body wt per day) for 7 days. When they were sacrificed 14 days after the last injection, serum levels of gonadotropins and testosterone and weights of accessory sex organs were decreased significantly, testicular 17-hydroxysteroid dehydroganase activity was suppressed and spermatogenesis was inhibited in 5.0% casein-fed estrogen-treated rats. Feeding of 20.0% casein diet to estrogen-treated rats resulted in increased serum concentration of gonadotropins and testosterone. LH and testosterone appeared to be normal in 20.0% casein-fed estrogen-treated rats while serum FSH levels remained subnormal. The estrogen-treated rats fed on 20.0% casein diet showed decreased spermatogenesis in comparison with control rats fed on 20.0% casein diet. Together, these results indicate that high casein diet stimulates synthesis of testicular testosterone and increases serum LH levels more than FSH in estrogen-treated rats. It is concluded that estrogen in the presence of high milk protein diet may be considered to be a suitable steroid hormone in the development of a male contraceptive.en_US
dc.description.affiliationDepartment of Physiology, Kathmandu Medical College, Duwakot, Kathmandu, Nepal. drnmbiswas@rediffmail.comen_US
dc.identifier.citationBiswas NM, Chattopadhyay A, Sarkar M. Hormonal contraceptive like effect of estrogen in milk protein-fed male rats. Nepal Medical College Journal. 2006 Jun; 8(2): 101-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/46871
dc.language.isoengen_US
dc.source.urihttps://www.nmcth.edu/list_journal_articles.phpen_US
dc.subject.mesh17-Hydroxysteroid Dehydrogenases --drug effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshContraceptive Agents --adverse effectsen_US
dc.subject.meshEstradiol --adverse effectsen_US
dc.subject.meshFollicle Stimulating Hormoneen_US
dc.subject.meshMaleen_US
dc.subject.meshMilk Proteinsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSpermatogenesis --drug effectsen_US
dc.titleHormonal contraceptive like effect of estrogen in milk protein-fed male rats.en_US
dc.typeJournal Articleen_US
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