Effects of piretanide on plasma fibrinolytic activity, platelet aggregation and platelet factor-4 release in man.
| dc.contributor.author | Chohan, I S | |
| dc.date.accessioned | 2015-07-25T11:34:12Z | |
| dc.date.available | 2015-07-25T11:34:12Z | |
| dc.date.issued | 1986-06 | |
| dc.description.abstract | Piretanide, 4-phenoxy-3-(pyrrolidinyl)-5-sulphamoyl benzoic acid, apart from being an efficient diuretic, enhances endogenous plasma fibrinolytic activity after a single dose of 6 mg administered by oral route. After ingestion of the drug, acceleration of fibrinolytic acitivity became manifest within 1 h, reached its peak in 3 h and was associated with a fall in fibrinogen and diminished urokinase excretion. Piretanide did not cause lysis of fibrin in vitro. Primary platelet aggregation, induced by adenosine-diphosphate, was inhibited by piretanide. In in vitro experiments piretanide led to effective inhibition of adenosine-diphosphate-induced platelet aggregation with complete inhibition at 5 mM concentration. Piretanide led to a highly significant decrease of platelet factor-4 release. | en_US |
| dc.identifier.citation | Chohan I S. Effects of piretanide on plasma fibrinolytic activity, platelet aggregation and platelet factor-4 release in man. Journal of Biosciences. 1986 June; 10(2): 243-249. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/160634 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ias.ac.in/jarch/jbiosci/10/243-249.pdf | en_US |
| dc.subject | Piretanide | en_US |
| dc.subject | synthetic fibrinolytic agent | en_US |
| dc.subject | anti-platelet agent | en_US |
| dc.subject | PF-4 release | en_US |
| dc.subject | diuretic | en_US |
| dc.title | Effects of piretanide on plasma fibrinolytic activity, platelet aggregation and platelet factor-4 release in man. | en_US |
| dc.type | Article | en_US |