Homocysteine and vascular disease.

dc.contributor.authorHankey, G Jen_US
dc.contributor.authorEikelboom, J Wen_US
dc.date.accessioned2000-11-08en_US
dc.date.accessioned2009-05-27T04:17:17Z
dc.date.available2000-11-08en_US
dc.date.available2009-05-27T04:17:17Z
dc.date.issued2000-11-08en_US
dc.description66 references.en_US
dc.description.abstractFor more than 20 years, moderately raised concentrations of total homocysteine have been associated with an increased risk of atherothrombotic vascular events but only recently has evidence mounted to suggest that the association may be causal. The association is independent of other factors, it is fairly consistent across many studies, it is strong and dose-related, and it is biologically plausible. However, the evidence needs to be strengthened by a systematic review of all comparable studies and the demonstration, in randomised trials, that lowering total homocysteine is followed by a significant reduction in atherothrombotic vascular disease. In addition, the measurement of total homocysteine needs to be standardised. If these can be achieved then total homocysteine measurement will become another useful marker of vascular risk, multivitamin therapy will be another therapeutic option for people at risk of atherothrombotic vascular disease, and fortification of food with folic acid will rise high on the political and public health agenda.en_US
dc.description.affiliationDepartment of Neurology, Royal Perth Hospital, Western Australia.en_US
dc.identifier.citationHankey GJ, Eikelboom JW. Homocysteine and vascular disease. Indian Heart Journal. 2000 Nov-Dec; 52(7 Suppl): S18-26en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/2782
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshHomocysteine --adverse effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshVascular Diseases --etiologyen_US
dc.titleHomocysteine and vascular disease.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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