A pilot study on observations on CD4 & CD8 counts in healthy HIV seronegative individuals.

Simple item page
dc.contributor.authorNag, V Len_US
dc.contributor.authorAgarwal, Pen_US
dc.contributor.authorVenkatesh, Ven_US
dc.contributor.authorRastogi, Pen_US
dc.contributor.authorTandon, Ren_US
dc.contributor.authorAgrawal, S Ken_US
dc.date.accessioned2002-08-21en_US
dc.date.accessioned2009-05-27T08:49:55Z
dc.date.available2002-08-21en_US
dc.date.available2009-05-27T08:49:55Z
dc.date.issued2002-08-21en_US
dc.description.abstractBACKGROUND & OBJECTIVES: CD4 T lymphocyte count is used to measure the progression of HIV infection and is recommended as part of the standard care of HIV infected person. Information on reference CD4 counts and CD4:CD8 ratio in healthy individuals is lacking in India. Therefore the present study was undertaken to obtain base-line data on CD4 counts and CD4:CD8 ratio of healthy population from north India and to assess the feasibility of using the values as reference in an extended larger study. METHODS: In this pilot study 84 HIV negative healthy volunteers (56 males, 28 females) in the age group of 20-59 yr and who were willing to participate in the study were enrolled after proper counseling. Blood specimens were collected from each subject and processed for anti-HIV antibodies for exclusion of HIV. CD4 and CD8 counts of the samples were performed by fluorescence activated cell sorting (FACS). RESULTS: The mean +/- SD of the absolute numbers of CD4 and CD8 lymphocytes/microliter was 763.6 +/- 226 and 547.5 +/- 190 in males and 797.9 +/- 263 and 567.7 +/- 250 in females. The range of the CD4 and CD8 counts was 365-1328 and 264-991 in males and 415-1257 and 224-1126 in females respectively. The mean +/- SD of the CD4:CD8 ratio was 1.47 +/- 0.42 in males and 1.52 +/- 0.45 in females. INTERPRETATION & CONCLUSION: The results of this study showed that there is wide variability in CD4 count in our population, as is seen in studies reported from other parts of India. A large multicentric study could define the normal range for CD4 and CD8 counts and CD4:CD8 ratio in the Indian population.en_US
dc.description.affiliationDepartment of Microbiology, King George's Medical College, Lucknow, India.en_US
dc.identifier.citationNag VL, Agarwal P, Venkatesh V, Rastogi P, Tandon R, Agrawal SK. A pilot study on observations on CD4 & CD8 counts in healthy HIV seronegative individuals. Indian Journal of Medical Research. 2002 Aug; 116(): 45-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/25785
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies --blooden_US
dc.subject.meshCD4-Positive T-Lymphocytes --immunologyen_US
dc.subject.meshCD8-Positive T-Lymphocytes --immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Infections --immunologyen_US
dc.subject.meshHIV Seronegativityen_US
dc.subject.meshHIV-1 --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshLymphocyte Counten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshReference Valuesen_US
dc.titleA pilot study on observations on CD4 & CD8 counts in healthy HIV seronegative individuals.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Research