Drug delivery through osmotic systems – An overview.
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Date
2011-04
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Abstract
The immediate release conventional dosage form lack in the efficiency of controlling the proper
plasma drug concentration. This results in the development of various controlled drug delivery
system. Among which the Pulsatile drug delivery systems (PDDS)/ osmotic drug delivery system
(ODDS) are gaining importance as these systems deliver the drug at specific time as per the path
physiological need of the disease, resulting in improved patient therapeutic efficacy and
compliance. They work on the principle of osmotic pressure for controlling the delivery of the
drug. The release of the drug is independent of physiological factors of the GIT to a large extent.
This review highlights’ the theoretical concept of drug delivery, history, types of oral osmotic drug
delivery systems, factors affecting the drug delivery system, advantages and disadvantages of this
delivery systems ,theoretical aspects, applications, marketed status and last but not the least the
recent development.
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Keywords
Osmotic drug delivery system, Osmotic pressure controlled formulation, Pulsatile drug delivery systems, Sandwich osmotic system
Citation
Ghosh Tanmoy, Ghosh Amitava. Drug delivery through osmotic systems – An overview. Journal of Applied Pharmaceutical Science. 2011 Apr; 1(2): 38-49.