Effectiveness of Bubble Continuous Positive Airway Pressure for Treatment of Children Aged 159 Months with Severe Pneumonia and Hypoxemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Simple item page
dc.contributor.authorTanashat, Mohammaden_US
dc.contributor.authorManasrah, AlMothanaen_US
dc.contributor.authorBataineh, Omar Abdullahen_US
dc.contributor.authorAbdelrazek, Ahmaden_US
dc.contributor.authorAbouzid, Mohameden_US
dc.date.accessioned2025-08-13T09:09:42Z
dc.date.available2025-08-13T09:09:42Z
dc.date.issued2025-06
dc.description.abstractOBJECTIVE Con?nuous posi?ve airway pressure (CPAP) is a standard treatment for children with moderate to severe respiratory distress; however, ven?lators are o?en unavailable in developing countries. Bubble CPAP (bCPAP) is considered a simple, cost effec?ve and less invasive alterna?ve to CPAP, however, its efficacy has not been assessed for children with pneumonia un?l recently. This meta-analysis aims to compare the effec?veness of bCPAP with low-flow oxygen for trea?ng severe pneumonia and hypoxemia in children. METHODS PubMed, EMBASE, Cochrane Library, Web of Science, and CENTRAL were searched to iden?fy eligible randomized controlled trials reported up to March 23, 2024. Outcomes were reported as risk ra?os (RRs) or mean difference (MD) and confidence intervals (CIs) using Review Manager so?ware. P value < 0.05 was considered sta?s?cally significant. RESULTS Three studies with 2030 pa?ents were included and revealed no significant difference between bCPAP and control in overall mortality [RR (95% CI) 0.46 (0.09, 2.32); P = 0.348], death during hospital stay [0.48 (0.02, 9.09), P = 0.619], composite primary outcome [0.48 (0.12, 1.97), P = 0.301], pneumothorax [1.94 (0.16, 23.11), P = 0.601], leaving hospital against medical advice [0.63 (0.16, 2.39), P = 0.489], and length of hospital stay [MD (95%CI) 0.15 days (? 0.66, 0.96), P = 0.706]. Children on bCPAP had significantly fewer events of severe hypoxemia [RR (95% CI) 0.22 (0.10, 0.49), P < 0.001], and less requirement for mechanical ven?la?on [RR (95% CI) 0.38 (0.15, 0.99), P = 0.048]. CONCLUSIONS bCPAP is not superior to low-flow oxygen for improving survival and reducing hospital stay in children with pneumonia, albeit the need for mechanical ven?la?on decreases.en_US
dc.identifier.affiliationsFaculty of Medicine, Yarmouk University, Irbid, Jordanen_US
dc.identifier.affiliationsDepartment of Internal Medicine, United Health Services- Wilson Medical Center, Johnson City, New York, USAen_US
dc.identifier.affiliationsFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordanen_US
dc.identifier.affiliationsMayo Clinic, Rochester, USAen_US
dc.identifier.affiliationsDepartment of Physical Pharmacy and Pharmacokine?cs, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3 St., 60- 806 Poznan, Poland; Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland.en_US
dc.identifier.citationTanashat Mohammad, Manasrah AlMothana, Bataineh Omar Abdullah, Abdelrazek Ahmad, Abouzid Mohamed. Effectiveness of Bubble Continuous Positive Airway Pressure for Treatment of Children Aged 159 Months with Severe Pneumonia and Hypoxemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Indian Pediatrics. 2025 Jun; 62(6): 440-450en_US
dc.identifier.issn0019-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/251351
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber6en_US
dc.relation.volume62en_US
dc.source.urihttps://indianpediatrics.net/june2025/440.pdfen_US
dc.subjectCPAPen_US
dc.subjectBubble CPAPen_US
dc.subjectSevere pneumoniaen_US
dc.titleEffectiveness of Bubble Continuous Positive Airway Pressure for Treatment of Children Aged 159 Months with Severe Pneumonia and Hypoxemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trialsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ip2025v62n6p440.pdf
Size:
139.47 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Pediatrics