Influences of vestibulo-cerebellum on kindling in the cat.

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dc.contributor.authorGuha, Den_US
dc.contributor.authorMaiti, A Ken_US
dc.date.accessioned1989-08-01en_US
dc.date.accessioned2009-05-27T08:22:22Z
dc.date.available1989-08-01en_US
dc.date.available2009-05-27T08:22:22Z
dc.date.issued1989-08-01en_US
dc.description.abstractThe development of amygdaloid kindling was assessed under conditions of pharmacological depression of the nodular areas of vestibulocerebellum and also following vestibular stimulation in chronically prepared cats. The results demonstrated that a single intra-nodular micro-injection of procaine hydrochlorides could significantly facilitate such epileptogenesis for at least several days. The number of kindling trials required to reach the first generalized convulsions was significantly increased by natural vestibular stimulation in comparison with control kindled animals. The intensity of fit, development of amygdaloid seizures and the convulsions were reduced markedly within a week by pre-conditioning the kindled animals with daily vestibular stimulation for 15-30 min. In addition, analysis of the behaviour of sleep-wake cycle indicated a significant increase in total sleep time and in the percentage of rapid eye movement (REM) sleep. These findings suggest that the natural rotational vestibular stimulation may result in a durable modification of brain function through development of enduring focal sensitization of catecholamine-mediated inhibitory mechanisms, reflecting the tonic inhibitory influences of the vestibulo-cerebellum in regulating the development and attenuation of epileptic states.en_US
dc.identifier.citationGuha D, Maiti AK. Influences of vestibulo-cerebellum on kindling in the cat. Indian Journal of Medical Research. 1989 Aug; 90(): 275-84en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/24217
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCatsen_US
dc.subject.meshCerebellum --physiologyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshKindling, Neurologic --physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRotationen_US
dc.subject.meshVestibule, Labyrinth --physiologyen_US
dc.titleInfluences of vestibulo-cerebellum on kindling in the cat.en_US
dc.typeJournal Articleen_US
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