Immunoprofile of Hodgkin's lymphoma in India.

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dc.contributor.authorPatkar, Nen_US
dc.contributor.authorMehta, Jen_US
dc.contributor.authorKulkarni, Ben_US
dc.contributor.authorPande, Ren_US
dc.contributor.authorAdvani, Sen_US
dc.contributor.authorBorges, Aen_US
dc.date.accessioned2009-05-28T06:21:17Z
dc.date.available2009-05-28T06:21:17Z
dc.date.issued2008-04-16en_US
dc.description.abstractAims and Background: The immunoprofile of the Reed Sternberg cell with respect to immunoreactivity for CD20 and lack of CD15 has been described as a poor prognostic factor. Large scale studies analyzing the immunoprofile of Hodgkin's lymphoma (HL) from India are lacking. The aim of this study was to obtain baseline information on relative frequencies and immunoprofiles of the two major types of HL and comparing reports from developed and developing countries. Materials and Methods: 451 cases of HL were classified as per the WHO into classical (n= 397) HL (cHL) and nodular lymphocyte predominant HL (NLPHL) (n=54). Cases of cHL were divided into 5 immunophenotypic groups; Group A (CD15+,CD30+,CD20-), Group B (CD15-,CD30+,CD20-), Group C (CD15+,CD30+,CD20+), Group D (CD15-,CD30+,CD20+)and Group E (CD15-,CD30-,CD20+). In cases of NLPHL, the immunophenotype of lymphocytes in the background, whether T(CD3) or B(CD20) rich was observed. Results: Most cases of cHL belonged to Group A (44.58%) followed by Group B (40.05%), C(5.54%), D(9.57%) and E(0.25%). Half, (50.89%) the cases of cHL were immunonegative for CD15, whereas CD20 was expressed by 15.61% of the cases. Three (5.55%) cases of NLPHL showed a CD3 (T) cell rich background. Significant differences were also observed with respect to the age distribution of cHL as compared to the west. Conclusion: Our study demonstrates that India has a high number of CD15 negative and a relatively higher number of CD20 positive cHL cases as compared to the western population. Favorable treatment response and good cure rates that one sees in western cHL may not apply to India.en_US
dc.description.affiliationDepartment of Histopathology, Asian Institute of Oncology, SL Raheja Hospital, Mumbai, India. nvpatkar@gmail.com.en_US
dc.identifier.citationPatkar N, Mehta J, Kulkarni B, Pande R, Advani S, Borges A. Immunoprofile of Hodgkin's lymphoma in India. Indian Journal of Cancer. 2008 Apr-Jun; 45(2): 59-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/49707
dc.language.isoengen_US
dc.source.urihttps://www.indianjcancer.comen_US
dc.titleImmunoprofile of Hodgkin's lymphoma in India.en_US
dc.typeJournal Articleen_US
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