Pathogenomics of uropathogenic Escherichia coli.
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Date
2012-04
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Abstract
Subset of faecal E. coli that can enter, colonize urinary tract and cause infection are known as uropathogenic E. coli (UPEC). UPEC strains act as opportunistic intracellular pathogens taking advantage of host susceptibility using a diverse array of virulence factors. Presence of specific virulence associated genes on genomic/pathogenicity islands and involvement of horizontal gene transfer appears to account for evolution and diversity of UPEC. Recent success in large-scale genome sequencing and comparative genomics has helped in unravelling UPEC pathogenomics. Here we review recent findings regarding virulence characteristics of UPEC and mechanisms involved in pathogenesis of urinary tract infection.
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Keywords
Pathogenesis of urinary tract infection, urinary tract infections, urovirulence factors, uropathogenic E. coli
Citation
Agarwal J, Srivastava S, Singh M. Pathogenomics of uropathogenic Escherichia coli. Indian Journal of Medical Microbiology. 2012 Apr-June; 30(2): 141-149.