Analysis of Spectral Domain - Optical Coherence Tomography and Fundus Autofluorescence in Typical Retinitis Pigmentosa.
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Date
2015-05
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Abstract
Purpose: To study fundus autofluorescence (FAF) and spectral domain-optical coherence tomography (SD-OCT)
characteristics in patients with typical retinitis pigmentosa (RP) and correlate them to visual acuity.
Design: Retrospective observational case series.
Methods: 110 eyes of 56 RP patients were included. FAF and SD-OCT imaging were done for all eyes. Extent of
the autofluorescence ring, central foveal thickness, photoreceptor outer-segment length (PROS), foveal outer segment
pigment epithelial thickness (FOSPET), and inner segment-outer segment (IS-OS) extent were defined and measured and
correlated to logMAR best corrected visual acuity (BCVA) using linear regression.
Results: Study included 110 eyes of 56 patients (34 male and 22 female). Mean BCVA was 0.33 logMAR with no
difference between genders. The mean age of patients was 15.4 ± 15.1 years. Mean autofluorescence extent was
3590 ± 1994 μm horizontally, and 2880 ± 1836 μm vertically. These values were significantly correlated with preserved
IS/OS junction extent (mean values horizontally = 2865 μm and vertically = 2464 μm). Mean central retinal thickness
(218.74 μm) and PROS (44.85 μm) were significantly correlated to BCVA with correlation coefficient r = –0.189,
P = 0.015; and r = –0.874, P = 0.0001, respectively. FOSPET (mean = 71.15 μm) did not show a significant correlation
with BCVA, independent of PROS.
Conclusions: Retinal microstructural changes as studied on SD-OCT, especially PROS length can be used as a surrogate
marker to monitor degenerative diseases such as RP. Further, studies are required to clearly delineate the microstructuralfunctional
relationship in the human retina.
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Keywords
Foveal outer segment pigment epithelial thickness, inner segment - outer segment junction, photoreceptor outer segment length, retinitis pigmentosa
Citation
Poornachandra B, Khurana Aruj K, Yadav Naresh Kumar, Battu Rajani, Shetty Rohit. Analysis of Spectral Domain - Optical Coherence Tomography and Fundus Autofluorescence in Typical Retinitis Pigmentosa. Journal of Vision Sciences, 2015 May-Aug; 1(2): 21-27.