Analysis of Spectral Domain - Optical Coherence Tomography and Fundus Autofluorescence in Typical Retinitis Pigmentosa.

Abstract
Purpose: To study fundus autofluorescence (FAF) and spectral domain-optical coherence tomography (SD-OCT) characteristics in patients with typical retinitis pigmentosa (RP) and correlate them to visual acuity. Design: Retrospective observational case series. Methods: 110 eyes of 56 RP patients were included. FAF and SD-OCT imaging were done for all eyes. Extent of the autofluorescence ring, central foveal thickness, photoreceptor outer-segment length (PROS), foveal outer segment pigment epithelial thickness (FOSPET), and inner segment-outer segment (IS-OS) extent were defined and measured and correlated to logMAR best corrected visual acuity (BCVA) using linear regression. Results: Study included 110 eyes of 56 patients (34 male and 22 female). Mean BCVA was 0.33 logMAR with no difference between genders. The mean age of patients was 15.4 ± 15.1 years. Mean autofluorescence extent was 3590 ± 1994 μm horizontally, and 2880 ± 1836 μm vertically. These values were significantly correlated with preserved IS/OS junction extent (mean values horizontally = 2865 μm and vertically = 2464 μm). Mean central retinal thickness (218.74 μm) and PROS (44.85 μm) were significantly correlated to BCVA with correlation coefficient r = –0.189, P = 0.015; and r = –0.874, P = 0.0001, respectively. FOSPET (mean = 71.15 μm) did not show a significant correlation with BCVA, independent of PROS. Conclusions: Retinal microstructural changes as studied on SD-OCT, especially PROS length can be used as a surrogate marker to monitor degenerative diseases such as RP. Further, studies are required to clearly delineate the microstructuralfunctional relationship in the human retina.
Description
Keywords
Foveal outer segment pigment epithelial thickness, inner segment - outer segment junction, photoreceptor outer segment length, retinitis pigmentosa
Citation
Poornachandra B, Khurana Aruj K, Yadav Naresh Kumar, Battu Rajani, Shetty Rohit. Analysis of Spectral Domain - Optical Coherence Tomography and Fundus Autofluorescence in Typical Retinitis Pigmentosa. Journal of Vision Sciences, 2015 May-Aug; 1(2): 21-27.