Mechanistic role of perfusion culture on bone regeneration

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dc.contributor.authorBirru, Bhaskaren_US
dc.contributor.authorMekala, Naveen Kumaren_US
dc.contributor.authorParcha, Sreenivasa Raoen_US
dc.date.accessioned2020-11-18T10:14:20Z
dc.date.available2020-11-18T10:14:20Z
dc.date.issued2019-03
dc.description.abstractBone tissue engineering (BTE) aims to develop engineered bone tissue to substitute conventional bone grafts. To achievethis, culturing the cells on the biocompatible three-dimensional (3D) scaffold is one alternative approach. The newfunctional bone tissue regeneration could be feasible by the synergetic combinations of cells, biomaterials and bioreactors.Although the field of biomaterial design/development for BTE applications attained reasonable success, development ofsuitable bioreactor remains still a major challenge. Tissue engineering bioreactors provide the microenvironment requiredfor neo-tissue regeneration, and also can be used to study the physio-chemical cues effect on cell proliferation anddifferentiation in order to produce functional tissue. In this direction, various bioreactors have been developed andevaluated for the successful development of engineered bone tissue. Continues assessment of tissue development andlimitations of the bioreactors lead to the progression of perfusion flow bioreactor system. Improvements in perfusion reactorsystem were able to yield multiple tissue engineered constructs with uniform cell distribution, easy to operate protocols andalso effectively handled for the functional tissue development to meet the adequate supply of engineered graft for clinicalapplication.en_US
dc.identifier.affiliationsDepartment of Biotechnology, National Institute of Technology, Warangal 506 004, TS, Indiaen_US
dc.identifier.affiliationsCollege of Medicine, Central Michigan University, Mt Pleasant 48858, USAen_US
dc.identifier.affiliationsDepartment of Biotechnology, National Institute of Technology, Warangal 506 004, TS, Indiaen_US
dc.identifier.citationBirru Bhaskar, Mekala Naveen Kumar, Parcha Sreenivasa Rao. Mechanistic role of perfusion culture on bone regeneration. Journal of Biosciences. 2019 Mar; 44(1): 1-9en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214295
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume44en_US
dc.source.urihttps://dx.doi.org//10.1007/s12038-018-9827-5en_US
dc.subjectBioreactoren_US
dc.subjectbone tissue engineeringen_US
dc.subjectPhysico-chemical cuesen_US
dc.subjectperfusion reactoren_US
dc.subject3D scaffoldsen_US
dc.titleMechanistic role of perfusion culture on bone regenerationen_US
dc.typeJournal Articleen_US
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