Clinical and histopathological spectrum of genital lichen sclerosus in 133 cases: Focus on the diagnosis of pre-sclerotic disease

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dc.contributor.authorAttili, Venkat Ratnamen_US
dc.contributor.authorAttili, S. K.en_US
dc.date.accessioned2023-08-10T07:30:27Z
dc.date.available2023-08-10T07:30:27Z
dc.date.issued2022-12
dc.description.abstractBackground: Early inflammatory lesions of lichen sclerosus are histopathologically difficult to diagnose until the hallmark of the disease i.e., papillary sclerosis becomes visible in histological sections. Pre-sclerotic and late or resolved phases of the disease have not been extensively studied. Methods: We retrospectively reviewed all cases diagnosed as genital lichen sclerosus over a ten-year period from 2006 to 2016, correlating the clinical findings with the histological features. Results: A total of 133 cases of genital lichen sclerosus (90 males and 43 females) were identified. Both genders demonstrated a similar histological spectrum. Fifty eight (44%) cases were identified as having pre-sclerotic lichen sclerosus, 64 (48%) as having progressive disease and 11 (8%) cases were classified as fully resolved with atrophy. Asymptomatic vitiligoid lesions were identified in 19 (14%) cases of which 12 were male. Low-grade squamous cell carcinoma was seen within the areas affected by long-standing lichen sclerosus, in four patients (3%, 2 male). Limitations: We studied only haematoxylin and eosin stained sections. The presence of basement membrane thickening could have been better illustrated with the periodic acid–Schiff stain. Conclusion: The pathogenesis of lichen sclerosus probably involves an immune reaction to the basement membrane at the epidermal interface and around the adnexa. The initial band of inflammation shifts gradually downwards from the epidermal interface into the dermis destroying the vascular channels and appendages, resulting in excessive deposition of altered extracellular matrix. Basilar infiltration of lymphocytes along with a grossly vacuolated or thickened basement membrane is proposed as the characteristic diagnostic feature of the pre-sclerotic stage. Greater awareness of the clinicopathological spectrum of lichen sclerosus should enable early diagnosis and treatment, thereby preventing structural damage and possible malignant transformation in chronic casesen_US
dc.identifier.affiliationsVisakha Institute of Skin and Allergy, Visakhapatnam, Andhra Pradesh, India.en_US
dc.identifier.citationAttili, Venkat Ratnamen_US
dc.identifier.citationAttili, S. K.. Clinical and histopathological spectrum of genital lichen sclerosus in 133 cases: Focus on the diagnosis of pre-sclerotic disease. Indian Journal of Dermatology, Venereology and Leprology. 2022 Dec; 88(6): 774-780en_US
dc.identifier.issn0973-3922
dc.identifier.issn0378-6323
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223065
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber6en_US
dc.relation.volume88en_US
dc.source.urihttps://doi.org/10.25259/IJDVL_640_20en_US
dc.subjectBasement membraneen_US
dc.subjectinterface dermatitisen_US
dc.subjectlichen sclerosusen_US
dc.subjectpre-scleroticen_US
dc.subjectvitiligoen_US
dc.titleClinical and histopathological spectrum of genital lichen sclerosus in 133 cases: Focus on the diagnosis of pre-sclerotic diseaseen_US
dc.typeJournal Articleen_US
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