Formulation and Evaluation Of Gastroretentive Losartan Floating Tablets.

Simple item page
dc.contributor.authorC, Madhavi
dc.contributor.authorY, Ramesh
dc.contributor.authorK, Sankar Rao
dc.contributor.authorA, Deepthi
dc.contributor.authorK, Gnana Prakash
dc.contributor.authorM, Gobinath
dc.date.accessioned2016-11-22T06:31:21Z
dc.date.available2016-11-22T06:31:21Z
dc.date.issued2015-07
dc.description.abstractThe objective of this research was to formulate and evaluate hydrodynamically balanced controlled drug delivery system of Losartan. This dosage form is associated with many advantages especially increased bioavailability and reduction in dosing frequency. The formulation was designed adopting optimization technique, which helps in setting up experiments in such a manner that the information is obtained as efficiently and precisely as possible. Initially, considering buoyancy as the main criteria, blank tablets were compressed for different formulae with various polymers like HPMC, MC and EC. The formula selected for design had a combination of Losartan, HPMC, EC and MC. The tablets were prepared by direct compression method and evaluated for Losartan content in vitro release profile and buoyancy. The dissolution study was carried out in simulated gastric fluid using USP dissolution test apparatus employing paddle stirrer. Duration of buoyancy was observed simultaneously when the dissolution has carried out The variation in weight was within the range of ±4% complying with pharmacopoeial specifications (±Z5%). The drug content of Losartan floating tablet 8.455±0.0085 mg in of optimized formulations indicating content uniformity. The buoyancy of the tablets was range 15.345±0.1321 hrs the maximum buoyancy was seen in P6, which has a high level of drug to polymer ratio. The in-vitro release was found to be in the range between the 79.12% to 90.45%.. The formulation P6 has an in vitro release of 79.12% showed the release of the drug in the controlled manner. The optimized formulation P6 exhibited responses that were comparable with that of the predicted values of the design in optimization technique. This indicates the suitability of the technique chosen for the present dosage form.en_US
dc.identifier.citationMadhavi C, Ramesh Y, Sankar Rao K, Deepthi A, Gnana Prakash K, Gobinath M. Formulation and Evaluation Of Gastroretentive Losartan Floating Tablets. World Journal of Clinical Pharmacology, Microbiology and Toxicology. 2015 July; 1(2): 26-35.en_US
dc.identifier.issn2454‐1729
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/178672
dc.language.isoenen_US
dc.subjectfloating tableten_US
dc.subjectGastro retentiveen_US
dc.subjecthydrodynamically balanceden_US
dc.subjectLosartanen_US
dc.subjectoptimizationen_US
dc.titleFormulation and Evaluation Of Gastroretentive Losartan Floating Tablets.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
wjcpmt2015v1n2p26.pdf
Size:
455.89 KB
Format:
Adobe Portable Document Format
Description:
Original article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
World Journal of Clinical Pharmacology, Microbiology and Toxicology