Amelioration of inflammatory responses by Chlorogenic acid via suppression of pro-inflammatory mediators.

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dc.contributor.authorChauhan, Prashant Singh
dc.contributor.authorSatti, Naresh Kumar
dc.contributor.authorSharma, Vijay Kumar
dc.contributor.authorDutt, Prabhu
dc.contributor.authorSuri, Krishan Avtar
dc.contributor.authorBani, Sarang
dc.date.accessioned2014-05-13T05:40:47Z
dc.date.available2014-05-13T05:40:47Z
dc.date.issued2011-06
dc.description.abstractThe premise of the present investigation was to evaluate the detailed anti-inflammatory properties of chlorogenic acid (CGA) and to delineate the possible mode of action. To explore the anti-inflammatory profile, we evaluated the effect of CGA on TNF-alpha expression (in vitro); carrageenan induced rat paw edema and carrageenan induce pleurisy (in vivo). In our studies, CGA significantly inhibited the TNF-alpha expression, paw edema and antioxidant enzymes in livers of rats in pre-treatment schedule but failed to exert any effect when administered 1 h after carrageenan injection. CGA was also found to be safe, as confirmed by the results of acute toxicity studies and MTT assay. CGA also caused reduction in total leucocytes count most probably by inhibiting neutrophils, but could not alter mononuclear cells count in carrageenan induced pleurisy. Inhibition of exudation was evidenced by the less exudate formation in CGA treated animals, which may be due to decrease in vascular permeability which was further confirmed in acetic acid induced vascular permeability model in mice where significant decrease in vascular permeability was observed. CGA was highly effective in reducing the arachidonic acid metabolites, nitric oxide and pro-inflammatory cytokines production in a dose dependent manner and in some conditions effect observed was almost comparable to ibuprofen. Result of the present investigation shows the anti-inflammatory effects of CGS in different models.en_US
dc.identifier.citationChauhan Prashant Singh, Satti Naresh Kumar, Sharma Vijay Kumar, Dutt Prabhu, Suri Krishan Avtar, Bani Sarang. Amelioration of inflammatory responses by Chlorogenic acid via suppression of pro-inflammatory mediators. Journal of Applied Pharmaceutical Science. 2011 Jun; 1(4): 67-75.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150788
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=62en_US
dc.subjectChlorogenic aciden_US
dc.subjectpro-inflammatory cytokinesen_US
dc.subjectnitric oxideen_US
dc.subjectPGE2en_US
dc.subjectLTB4en_US
dc.titleAmelioration of inflammatory responses by Chlorogenic acid via suppression of pro-inflammatory mediators.en_US
dc.typeArticleen_US
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