Effect of erythromycin and cisapride on emptying of the vagally denervated intrathoracic stomach.

Simple item page
dc.contributor.authorNarasimhan, Ren_US
dc.contributor.authorMittal, B Ren_US
dc.contributor.authorGupta, N Men_US
dc.date.accessioned2002-07-16en_US
dc.date.accessioned2009-06-04T03:32:51Z
dc.date.available2002-07-16en_US
dc.date.available2009-06-04T03:32:51Z
dc.date.issued2002-07-16en_US
dc.description.abstractBACKGROUND: Subsequent to esophagectomy and reconstruction among patients with esophageal cancers, the intrathoracic denervated stomach acts as a passive conduit without peristalsis. OBJECTIVE: The study was designed to assess the impact of two prokinetic drugs viz. erythromycin and cisapride on the emptying of vagally denervated intrathoracic stomach. METHODS: Twenty consecutive patients of carcinoma esophagus, who had undergone one stage transhiatal oesophagectomy with cervical esophagogastrostomy and were disease free at three months postoperative follow-up, were included in the study. These patients were randomised into two groups of ten each. The patients in group A received erythromycin, while patients in group B received cisapride. The gastric emptying was studied by scintigraphy, using a standard test meal containing 99m Tc sulphur colloid labelled 'IDLIS' [rice based radio labelled food] before and after the drug treatment. RESULTS: The pre and post treatment mean gastric half emptying time of the patients in the erythromycin group was 52.6 min and 49.7 min (p > 0.1) and in cisapride group it was 53.76 and 26.4 min respectively (p < 0.05). Intergroup comparison of the difference was not statistically significant. CONCLUSION: Cisapride is an effective prokinetic agent in the treatment of gastric stasis of the vagally denervated intrathoracic stomach.en_US
dc.description.affiliationDepartment of Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh-160 012.en_US
dc.identifier.citationNarasimhan R, Mittal BR, Gupta NM. Effect of erythromycin and cisapride on emptying of the vagally denervated intrathoracic stomach. Tropical Gastroenterology. 2002 Jul-Sep; 23(3): 122-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/124347
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshCisapride --pharmacologyen_US
dc.subject.meshErythromycin --pharmacologyen_US
dc.subject.meshEsophageal Neoplasms --surgeryen_US
dc.subject.meshEsophagectomy --adverse effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Emptying --drug effectsen_US
dc.subject.meshGastrointestinal Agents --pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshStomach --innervationen_US
dc.subject.meshVagotomy --adverse effectsen_US
dc.titleEffect of erythromycin and cisapride on emptying of the vagally denervated intrathoracic stomach.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Tropical Gastroenterology