Stem cell therapy: A novel & futuristic treatment modality for disaster injuries.

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dc.contributor.authorGurudutta, G U
dc.contributor.authorSatija, Neeraj Kumar
dc.contributor.authorSingh, Vimal Kishor
dc.contributor.authorVerma, Yogesh Kumar
dc.contributor.authorGupta, Pallavi
dc.contributor.authorTripathi, R P
dc.date.accessioned2012-03-28T05:29:21Z
dc.date.available2012-03-28T05:29:21Z
dc.date.issued2012-01
dc.description.abstractStem cell therapy hold the potential to meet the demand for transplant cells/tissues needed for treating damages resulting from both natural and man-made disasters. Pluripotency makes embryonic stem cells and induced pluripotent stem cells ideal for use, but their teratogenic character is a major hindrance. Therapeutic benefits of bone marrow transplantation are well known but characterizing the potentialities of haematopoietic and mesenchymal cells is essential. Haematopoietic stem cells (HSCs) have been used for treating both haematopoietic and non-haematopoietic disorders. Ease of isolation, in vitro expansion, and hypoimmunogenecity have brought mesenchymal stem cells (MSCs) into limelight. Though differentiation of MSCs into tissue-specific cells has been reported, differentiation-independent mechanisms seem to play a more significant role in tissue repair which need to be addressed further. The safety and feasibility of MSCs have been demonstrated in clinical trials, and their use in combination with HSC for radiation injury treatment seems to have extended benefit. Therefore, using stem cells for treatment of disaster injuries along with the conventional medical practice would likely accelerate the repair process and improve the quality of life of the victim.en_US
dc.identifier.citationGurudutta G U, Satija Neeraj Kumar, Singh Vimal Kishor, Verma Yogesh Kumar, Gupta Pallavi, Tripathi R P. Stem cell therapy: A novel & futuristic treatment modality for disaster injuries. Indian Journal of Medical Research. 2012 Jan; 135(1): 15-25.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/137366
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307178/en_US
dc.subjectCritical injuriesen_US
dc.subjectdisastersen_US
dc.subjecthaematopoietic stem cellsen_US
dc.subjectmesenchymal stem cellsen_US
dc.subjectstem cell therapyen_US
dc.subject.meshAcute Radiation Syndrome --therapy
dc.subject.meshDisasters
dc.subject.meshHematopoietic Stem Cell Transplantation --methods
dc.subject.meshHumans
dc.subject.meshMass Casualty Incidents
dc.subject.meshMesenchymal Stem Cell Transplantation --methods
dc.subject.meshMusculoskeletal System --injuries
dc.subject.meshNuclear Reactors
dc.subject.meshSpinal Cord Injuries --therapy
dc.subject.meshTissue Therapy --methods
dc.subject.meshWounds and Injuries --therapy
dc.titleStem cell therapy: A novel & futuristic treatment modality for disaster injuries.en_US
dc.typeArticleen_US
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