Need for 25 mg tablets of phenytoin.

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dc.contributor.authorKshirsagar, N Aen_US
dc.contributor.authorJoshi, M Ven_US
dc.contributor.authorShah, P Uen_US
dc.contributor.authorDalvi, S Sen_US
dc.date.accessioned1991-05-01en_US
dc.date.accessioned2009-05-30T22:22:11Z
dc.date.available1991-05-01en_US
dc.date.available2009-05-30T22:22:11Z
dc.date.issued1991-05-01en_US
dc.description.abstractPhenytoin is widely used for the treatment of generalized tonic clonic and partial seizures. Monitoring of serum phenytoin levels is essential to optimize therapy. Of 320 patients monitored, 190 patients whose seizures were uncontrolled were followed up before and after dosage adjustment was carried out. Plasma phenytoin estimation was done by HPLC method. Of all the patients receiving the drug, 20% and 8% of patients were finally on dosages requiring 50 and 25 mg fraction administration respectively. Administration of 100 mg fractions resulted in either loss of seizure control or toxicity. This emphasizes the need for providing tablets of 25 mg strength, presently not available in this country.en_US
dc.description.affiliationDepartment of Pharmacology & Clinical Pharmacology, Seth GS Medical College, Parel, Bombay.en_US
dc.identifier.citationKshirsagar NA, Joshi MV, Shah PU, Dalvi SS. Need for 25 mg tablets of phenytoin. Journal of the Association of Physicians of India. 1991 May; 39(5): 395-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/89463
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshElectroencephalography --drug effectsen_US
dc.subject.meshEpilepsy, Tonic-Clonic --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenytoin --administration & dosageen_US
dc.titleNeed for 25 mg tablets of phenytoin.en_US
dc.typeJournal Articleen_US
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