Effect of superoxide dismutase and acidified sodium nitrite on infarct size following ischemia and reperfusion in dogs.

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dc.contributor.authorTripathi, Yen_US
dc.contributor.authorHegde, B Men_US
dc.contributor.authorRaghuveer, C Ven_US
dc.date.accessioned1997-07-01en_US
dc.date.accessioned2009-06-01T07:39:53Z
dc.date.available1997-07-01en_US
dc.date.available2009-06-01T07:39:53Z
dc.date.issued1997-07-01en_US
dc.description.abstractThe effects of superoxide dismutase (SOD) alone or in combination with acidified sodium nitrite (NaNO2), a liberator of nitric oxide were examined in dogs after ischemia and reperfusion. Animals were divided into five groups. Left anterior descending coronary artery was occluded for 90 min followed by 4 hours of reperfusion with or without therapeutic interventions given preceding reperfusion. Left ventricular end diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP) and ECG changes were monitored throughout the study. Area at risk was defined by Evans blue and area of infarction by incubation in triphenyltetrazolium. Myocardial tissue lipid peroxidation was measured in ischemic and non-ischemic zones. There was no evidence of infarction until ninety minutes of ischemia. Percentage area of necrosis vis-a-vis area at risk percentage necrosis in left vertricular mass was significantly low in animals treated with combination of SOD and NaNO2 in comparison with isolated treatment with saline, SOD or NaNO2. LVEDP increased significantly following ischemia and remained unchanged during saline reperfusion. Treatment with SOD, NaNO2 in isolation or its combination significantly lowered LVEDP. Maximum increase in tissue lipid peroxidation was observed in saline and NaNO2 treated animals. SOD alone or in combination with NaNO2 significantly lowered the lipid peroxidation. The results clearly demonstrate that reperfusion can cause necrosis in ischemic myocardium. Combined treatment with SOD and NaNO2 offers significant cardioprotection against oxidative stress.en_US
dc.description.affiliationDepartment of Physiology, Kasturba Medical College, Mangalore.en_US
dc.identifier.citationTripathi Y, Hegde BM, Raghuveer CV. Effect of superoxide dismutase and acidified sodium nitrite on infarct size following ischemia and reperfusion in dogs. Indian Journal of Physiology and Pharmacology. 1997 Jul; 41(3): 248-56en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108327
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshHeart --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Infarction --drug therapyen_US
dc.subject.meshMyocardium --pathologyen_US
dc.subject.meshProtective Agents --therapeutic useen_US
dc.subject.meshReperfusion Injury --pathologyen_US
dc.subject.meshSodium Nitrite --therapeutic useen_US
dc.subject.meshSuperoxide Dismutase --therapeutic useen_US
dc.subject.meshVentricular Function, Left --drug effectsen_US
dc.titleEffect of superoxide dismutase and acidified sodium nitrite on infarct size following ischemia and reperfusion in dogs.en_US
dc.typeJournal Articleen_US
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