Active pharmaceutical ingredient (api) from an estuarine fungus, Microdochium nivale (Fr.).
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Date
2011-09
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Abstract
Various marine habitats sustain variety of bio-sources of ecological and biotech potentials. Pharmaceutical
potential compound Cyclosporine A was reported from marine fungus Microdochium nivale associated with
Porteresia coarctata, a marine salt marsh grass from mangrove environment distributed along the Central
West Coast (CWC) of India. This study involves association of M. nivale with P. coarctata plant, fermentation
conditions, purification of Cyclosporine A, chemical characterization etc. Its antifungal inhibition and MIC
(Minimum inhibitory concentration) against Aspergillus strains (A. niger, A. japonicus, A. fresenii), yeasts and
dermatophytes (Candida sp., Cryptococcus neoformans, Trichophyton mentagrophytes, T. tonsurans, T.
violaceum, Microsporium gypsum and Fusarium sp.) were evaluated. However, the MIC against A. japonicus,
C. neoformans, Candida sp. and T. tonsurans were confirmed to be as low as 12.5-25 mg disc-1. The
antifungal properties of Cyclosporine A against Aspergillus species, yeast and dermatophytes revealed that
Cyclosporine A would be a potential compound for life threatening diseases caused by above fungi in both
human and animals. Furthermore, we have reported herewith another source of Cyclosporin A derived from
filamentous fungus, M. nivale. occurring in marine environment.
Description
Keywords
Microdochium nivale, Cyclosporine A, Antifungal, Estuarine environment
Citation
Bhosale S H, Patil K B, Parameswaran P S, Naik C G, Jagtap T G. Active pharmaceutical ingredient (api) from an estuarine fungus, Microdochium nivale (Fr.). Journal of Environmental Biology. 2011 Sept; 32(5): 653-658.