A comparison of the efficacy of sublingual and oral misoprostol 400 microgram in the management of early pregnancy failure: a randomized controlled trial.

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dc.contributor.authorAyudhaya, Orada Patamasingh Naen_US
dc.contributor.authorHerabutya, Yongyothen_US
dc.contributor.authorChanrachakul, Boonsrien_US
dc.contributor.authorAyuthaya, Nathpong Israngura Naen_US
dc.contributor.authorO-Prasertsawat, Prataken_US
dc.date.accessioned2009-05-27T21:15:58Z
dc.date.available2009-05-27T21:15:58Z
dc.date.issued2006-10-30en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To compare repeated doses of sublingual with oral misoprostol in the medical management of early pregnancy failure. MATERIAL AND METHOD: One hundred and thirty eight women with a period of gestation less than 20 week calculated by her last menstrual period and less than 12 weeks by size were sequentially allocated to two groups to receive either 400 microg of misoprostol orally or sublingually every 4 hours until termination of pregnancy was completed. RESULTS: There is no difference in the mean induction to abortion interval. Fever and chill were more common in sublingual group compared with oral group. The other adverse effects were similar and included nausea, vomiting, diarrhea, abdominal pain, and headache. CONCLUSION: Sublingual misoprostol is as effective as oral route. Most adverse effects are similar in both groups except fever was more common in sublingual group.en_US
dc.description.affiliationDepartment of Obstetrics and Gyneacology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama 6 Rd, Rachavithee, Bangkok 10400, Thailand.en_US
dc.identifier.citationAyudhaya OP, Herabutya Y, Chanrachakul B, Ayuthaya NI, O-Prasertsawat P. A comparison of the efficacy of sublingual and oral misoprostol 400 microgram in the management of early pregnancy failure: a randomized controlled trial. Journal of the Medical Association of Thailand. 2006 Oct; 89 Suppl 4(): S5-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44488
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAbortifacient Agents, Nonsteroidal --administration & dosageen_US
dc.subject.meshAbortion, Induced --methodsen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdministration, Sublingualen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMisoprostol --administration & dosageen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complicationsen_US
dc.subject.meshTime Factorsen_US
dc.titleA comparison of the efficacy of sublingual and oral misoprostol 400 microgram in the management of early pregnancy failure: a randomized controlled trial.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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