Initial trends of individual donation nucleic acid testing in voluntary & replacement donors from a tertiary care centre in north India

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dc.contributor.authorHans, Ren_US
dc.contributor.authorMarwaha, Nen_US
dc.contributor.authorSharma, Sen_US
dc.contributor.authorSachdev, Sen_US
dc.contributor.authorSharma, RRen_US
dc.date.accessioned2020-04-10T01:42:37Z
dc.date.available2020-04-10T01:42:37Z
dc.date.issued2019-05
dc.description.abstractBackground & objectives: Individual donation nucleic acid testing (ID-NAT) is considered as sensitive technology to assess blood safety from viral transfusion-transmissible infections (TTIs) in blood donors. The present study was aimed to analyze the results of ID-NAT for three years (2013-2015) with special reference to different types of donors and their age ranges in a tertiary care centre in north India. Methods: The results of ID-NAT for three years were retrospectively analyzed at our centre. A total of 168,433 donations were tested with ID-NAT, of which 10,467 were tested with Procleix® Ultrio® reagents and 157,966 were tested with Procleix®UltrioPlus® reagents, and the results were compared with those of serology to calculate the NAT yield in voluntary, replacement, first-time and repeat donors. Results: A combined NAT yield was observed as one in 1031 out of 167,069 seronegative donations with HBV yield as one in 1465, HCV yield as one in 3885 and HIV-1 as one in 167,069. Yield for co-infection (HCV and HBV) was one in 41,767. A high NAT yield was observed in replacement donors (1 in 498) as compared to voluntary donors (1 in 1320). Interpretation & conclusions: Addition of NAT to serology improved the blood safety in our centre interdicting possibility of 150 TTIs annually. It has also reemphasized the safety of voluntary over replacement donors. The results also highlight the need of proper counselling, notification and referral guidelines of NAT yield donors in our country and other countries which lack them.en_US
dc.identifier.affiliationsDepartment of Transfusion Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, Indiaen_US
dc.identifier.citationHans R, Marwaha N, Sharma S, Sachdev S, Sharma RR. Initial trends of individual donation nucleic acid testing in voluntary & replacement donors from a tertiary care centre in north India. Indian Journal of Medical Research. 2019 May; 149(5): 633-640en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195872
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber5en_US
dc.relation.volume149en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_822_17en_US
dc.subjectFirst-time donoren_US
dc.subjectindividual donation nucleic acid testingen_US
dc.subjectnucleic acid testing yielden_US
dc.subjectrepeat donorsen_US
dc.subjectreplacement donor -voluntary donoren_US
dc.titleInitial trends of individual donation nucleic acid testing in voluntary & replacement donors from a tertiary care centre in north Indiaen_US
dc.typeJournal Articleen_US
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