Physiological, biochemical and histological changes due to physostigmine in monkeys.

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dc.contributor.authorJeevaratnam, Ken_US
dc.contributor.authorDasgupta, Sen_US
dc.contributor.authorPravinkumar,en_US
dc.contributor.authorPant, S Cen_US
dc.contributor.authorSachan, A Sen_US
dc.contributor.authorSelvamurthy, Wen_US
dc.contributor.authorRay, U Sen_US
dc.contributor.authorMukhopadhyay, Sen_US
dc.contributor.authorPurkayastha, S Sen_US
dc.date.accessioned1998-01-26en_US
dc.date.accessioned2009-06-01T08:04:30Z
dc.date.available1998-01-26en_US
dc.date.available2009-06-01T08:04:30Z
dc.date.issued1998-01-26en_US
dc.description.abstractPhysostigmine (Phy), a short-acting reversible anticholinesterase agent is considered to be a potent prophylactic antidote for the highly toxic organophosphorous (OP) compounds. The toxic effects, if any, of the probable prophylactic doses of Phy have been evaluated by studying its physiological, biochemical and histological effects in monkeys. Phy only at 100 micrograms/kg resulted in certain cholinergic signs such as salivation, lacrymation and muscular faciculations; physiological changes such as mild tachycardia, tachypnea, higher amplitude in electrical activity of the brain, clinico-chemical effects like fall in PO2, PCO2 and alkalosis and histologically an inflammatory reaction in the lungs. On the other hand, the lower dose, i.e. 50 micrograms/kg appeared to be devoid of cholinergic signs and symptoms. However, we observed a significant inhibition of both plasma and erythrocyte ChE and increase in the rectal temperature in both the Phy treated groups. From this study, Phy at a dose of 50 micrograms/kg could be inferred as a safe, sign free intramuscular dose and may probably be used in pretreatment regimen against nerve agents.en_US
dc.description.affiliationDefence Research & Development Establishment, Gwalior.en_US
dc.identifier.citationJeevaratnam K, Dasgupta S, Pravinkumar , Pant SC, Sachan AS, Selvamurthy W, Ray US, Mukhopadhyay S, Purkayastha SS. Physiological, biochemical and histological changes due to physostigmine in monkeys. Indian Journal of Physiology and Pharmacology. 1998 Jan; 42(1): 25-38en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108639
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshBody Temperature --drug effectsen_US
dc.subject.meshCholinesterase Inhibitors --toxicityen_US
dc.subject.meshCholinesterases --blooden_US
dc.subject.meshElectroencephalography --drug effectsen_US
dc.subject.meshHeart Rate --drug effectsen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshLung --drug effectsen_US
dc.subject.meshMacaca mulattaen_US
dc.subject.meshMaleen_US
dc.subject.meshOxygen --blooden_US
dc.subject.meshPhospholipids --metabolismen_US
dc.subject.meshPhysostigmine --toxicityen_US
dc.titlePhysiological, biochemical and histological changes due to physostigmine in monkeys.en_US
dc.typeJournal Articleen_US
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