Role of citicoline in improvement of cognition, memory and post stroke disability in stroke patients

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dc.contributor.authorSingh, Mahendrapalen_US
dc.contributor.authorKhan, Mohd. Imranen_US
dc.contributor.authorGiri, Richaen_US
dc.contributor.authorKumar, Laliten_US
dc.date.accessioned2020-04-09T07:41:27Z
dc.date.available2020-04-09T07:41:27Z
dc.date.issued2019-03
dc.description.abstractBackground: Citicoline has emerged as a potential neuroprotectant in experimental models in stroke patients. Citicoline has shown some beneficial effects in human ischaemic stroke and with an excellent safety profile while in haemorrhagic stroke data is limited. Authors conducted this study to test role of citicoline in stroke patients in terms of cognition, memory and post stroke disability.Methods: In this prospective study, patients had to be previously independent, aged >18 years of age, presented within 24 hours of onset of symptoms of stroke diagnosed by neuroimaging (CT or MRI). Patients received either a placebo or 500 mg/12 h citicoline for 12 weeks (orally or intravenously). The primary aim was to evaluate improvement in cognition, memory and post stroke disability after 12 weeks. The efficacy endpoint was the percentage of subjects with MMSE and DRS at 12 weeks.Results: Total 75 stroke patients were enrolled, 40 in control group and 35 in citicoline group were allotted randomly. Patients in citicoline group were given intravenous citicoline 500 mg/12 hour during hospital stay and orally 500 mg/12 hour after discharge for up to 12 weeks. Control Group was given Placebo. cognition, memory and post stroke disability show positive improvement in citicoline group.Conclusions: Citicoline shows beneficial effects in stroke in terms of cognition, memory and post stroke disability.en_US
dc.identifier.affiliationsDepartment of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.citationSingh Mahendrapal, Khan Mohd. Imran, Giri Richa, Kumar Lalit. Role of citicoline in improvement of cognition, memory and post stroke disability in stroke patients. International Journal of Advances in Medicine. 2019 Mar; 6(2): 429-434en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194245
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20191154en_US
dc.subjectCiticolineen_US
dc.subjectNeuroprotectionen_US
dc.subjectPost-stroke disabilityen_US
dc.titleRole of citicoline in improvement of cognition, memory and post stroke disability in stroke patientsen_US
dc.typeJournal Articleen_US
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