Association of high sensitivity C-reactive protein concentrations and metabolic syndrome among Thai adults.
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Date
2010-06
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Abstract
Background: Limited information is available regarding associations of metabolic syndrome with C-reactive
protein (CRP) concentrations among Asian populations.
Objective: Investigate the association of high sensitivity CRP (hsCRP) concentrations and metabolic syndrome
among Thai adults.
Methods: This cross-sectional study was comprised of 467 Thai participants (209 men and 258 women) receiving
annual health check-up. Spearman’s rank correlation coefficients were used to assess the associations between
metabolic parameters (age, waist circumference, blood pressure, triglycerides, HDL-C, fasting plasma glucose,
fasting insulin and uric acid) with hsCRP concentrations for men and women, respectively. Multivariable logistic
regression procedures were used to estimate the risk (odds ratios (OR), and 95% confidence intervals (CI) of
metabolic syndrome according to low, moderate, and high hsCRP concentrations (<1.0, 1.0-3.0, and >3.0 mg/L,
respectively).
Results: Measures of adiposity and fasting insulin were positively and significantly correlated with hsCRP
concentrations among women with and without metabolic syndrome. Similar associations were observed among
men without metabolic syndrome. After controlling for confounders, moderately elevated hsCRP concentrations
were associated with a 2.38-fold increased risk of metabolic syndrome (OR=2.38, 95%CI=1.20-4.72) among men.
Men with high hsCRP concentrations had a 5.45-fold increased risk of metabolic syndrome (OR=5.45, 95%CI=2.24-
13.27) when compared with those who had low hsCRP concentrations. The corresponding OR for women with
moderately elevated and high hsCRP concentrations were 4.92 (OR=4.92, 95%CI=2.34-10.35) and 11.93 (OR=11.93,
95%CI=5.54-25.72), respectively.
Conclusions: These findings are consistent with the literature suggesting a role of hsCRP as a biomarker for
metabolic syndrome.
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Keywords
C-reactive protein, inflammation, metabolic syndrome, obesity
Citation
Asian Biomedicine (Research Reviews and News); Vol. 4 No. 3 Jun 2010; 385-393.