Molecular genetics of schizophrenia: past, present and future.

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dc.contributor.authorPrasad, Sumanen_US
dc.contributor.authorSemwal, Prachien_US
dc.contributor.authorDeshpande, Smitaen_US
dc.contributor.authorBhatia, Triptishen_US
dc.contributor.authorNimgaonkar, V Len_US
dc.contributor.authorThelma, B Ken_US
dc.date.accessioned2002-02-03en_US
dc.date.accessioned2009-06-01T14:19:50Z
dc.date.available2002-02-03en_US
dc.date.available2009-06-01T14:19:50Z
dc.date.issued2002-02-03en_US
dc.description205 references.en_US
dc.description.abstractSchizophrenia is a severe neuropsychiatric disorder with a polygenic mode of inheritance which is also governed by non-genetic factors. Candidate genes identified on the basis of biochemical and pharmacological evidence are being tested for linkage and association studies. Neurotransmitters, especially dopamine and serotonin have been widely implicated in its etiology. Genome scan of all human chromosomes with closely spaced polymorphic markers is being used for linkage studies. The completion and availability of the first draft of Human Genome Sequence has provided a treasure-trove that can be utilized to gain insight into the so far inaccessible regions of the human genome. Significant technological advances for identification of single nucleo-tide polymorphisms (SNPs) and use of microarrays have further strengthened research methodologies for genetic analysis of complex traits. In this review, we summarize the evolution of schizophrenia genetics from the past to the present, current trends and future direction of research.en_US
dc.description.affiliationDepartment of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi 110 021, India.en_US
dc.identifier.citationPrasad S, Semwal P, Deshpande S, Bhatia T, Nimgaonkar VL, Thelma BK. Molecular genetics of schizophrenia: past, present and future. Journal of Biosciences. 2002 Feb; 27(1 Suppl 1): 35-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110752
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAnticipation, Geneticen_US
dc.subject.meshCatechol O-Methyltransferase --geneticsen_US
dc.subject.meshChromosomes, Human --geneticsen_US
dc.subject.meshDopamine Plasma Membrane Transport Proteinsen_US
dc.subject.meshGenome, Humanen_US
dc.subject.meshHistory, 20th Centuryen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMembrane Glycoproteinsen_US
dc.subject.meshMembrane Transport Proteins --geneticsen_US
dc.subject.meshMolecular Biologyen_US
dc.subject.meshMonoamine Oxidase --geneticsen_US
dc.subject.meshNerve Tissue Proteinsen_US
dc.subject.meshPolymorphism, Single Nucleotide --geneticsen_US
dc.subject.meshReceptors, Dopamine --geneticsen_US
dc.subject.meshReceptors, Serotonin --geneticsen_US
dc.subject.meshSchizophrenia --geneticsen_US
dc.subject.meshTyrosine 3-Monooxygenase --geneticsen_US
dc.titleMolecular genetics of schizophrenia: past, present and future.en_US
dc.typeHistorical Articleen_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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