Malignancies in Down syndrome.

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dc.contributor.authorKusumakumary, Pen_US
dc.contributor.authorVats, T Sen_US
dc.contributor.authorAnkathil, Ren_US
dc.contributor.authorGattamaneni, H Ren_US
dc.contributor.authorNair, M Ken_US
dc.date.accessioned1997-11-20en_US
dc.date.accessioned2009-05-30T11:39:40Z
dc.date.available1997-11-20en_US
dc.date.available2009-05-30T11:39:40Z
dc.date.issued1997-11-20en_US
dc.description.abstractDown Syndrome (DS) is associated with an increased incidence of malignancies, especially leukaemias. We came across 8 DS children presenting with malignancies and having trisomy 21 as the sole cytogenetic abnormality. Of these 8 DS cases, 4 presented with acute lymphocytic leukaemia, 2 with acute myeloid leukaemia and one case each with Hodgkin's disease and Wilms' tumour. There are contradictory reports regarding the distribution of myeloid versus lymphoid malignancies in DS children and their response to therapy. The exact mechanism by which patients with DS are predisposed to develop malignancies is unclear. However, presence of the extra chromosome no. 21 is presumed to disrupt the genetic balance which increases generalized susceptibility to genetic and environmental trauma. Furthermore, an increased methotrexate toxicity observed in these patients should also be taken into consideration in designing treatment for DS children with malignancies.en_US
dc.description.affiliationRegional Cancer Centre, Thiruvananthapuram, Kerala.en_US
dc.identifier.citationKusumakumary P, Vats TS, Ankathil R, Gattamaneni HR, Nair MK. Malignancies in Down syndrome. Indian Journal of Pediatrics. 1997 Nov-Dec; 64(6): 873-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/79901
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshComorbidityen_US
dc.subject.meshData Collectionen_US
dc.subject.meshDown Syndrome --epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition to Diseaseen_US
dc.subject.meshHematologic Neoplasms --epidemiologyen_US
dc.subject.meshHodgkin Disease --epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshKidney Neoplasms --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshWilms Tumor --epidemiologyen_US
dc.titleMalignancies in Down syndrome.en_US
dc.typeJournal Articleen_US
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