Evolution of ageing since Darwin.

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dc.contributor.authorRose, Michael Ren_US
dc.contributor.authorBurke, Molly Ken_US
dc.contributor.authorShahrestani, Parvinen_US
dc.contributor.authorMueller, Laurence Den_US
dc.date.accessioned2008-12-17en_US
dc.date.accessioned2009-06-02T07:32:04Z
dc.date.available2008-12-17en_US
dc.date.available2009-06-02T07:32:04Z
dc.date.issued2008-12-17en_US
dc.description.abstractIn the late 19th century, the evolutionary approach to the problem of ageing was initiated by August Weismann, who argued that natural selection was more important for ageing than any physiological mechanism. In the mid-twentieth century, J. B. S. Haldane, P. B. Medawar and G. C. Williams informally argued that the force of natural selection falls with adult age. In 1966, W. D. Hamilton published formal equations that showed mathematically that two 'forces of natural selection' do indeed decline with age, though his analysis was not genetically explicit. Brian Charlesworth then developed the required mathematical population genetics for the evolution of ageing in the 1970's. In the 1980's, experiments using Drosophila showed that the rate of ageing evolves as predicted by Hamilton's 'forces of natural selection'. The discovery of the cessation of ageing late in life in the 1990's was followed by its explanation in terms of evolutionary theory based on Hamilton's forces. Recently, it has been shown that the cessation of ageing can also be manipulated experimentally using Hamilton's 'forces of natural selection'. Despite the success of evolutionary research on ageing, mainstream gerontological research has largely ignored both this work and the opportunity that it provides for effective intervention in ageing.en_US
dc.description.affiliationDepartment of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697-2525, USA. mrrose@uci.eduen_US
dc.identifier.citationRose MR, Burke MK, Shahrestani P, Mueller LD. Evolution of ageing since Darwin. Journal of Genetics. 2008 Dec; 87(4): 363-71en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/114524
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jgenet/index.htmlen_US
dc.titleEvolution of ageing since Darwin.en_US
dc.typeJournal Articleen_US
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