Study of Prevalence of Koilocytes in Oral Squamous Cell Carcinoma

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dc.contributor.authorSmitha, T.en_US
dc.contributor.authorMohan, C.V.en_US
dc.contributor.authorHemavathy, S.en_US
dc.date.accessioned2019-12-02T09:48:38Z
dc.date.available2019-12-02T09:48:38Z
dc.date.issued2016-06
dc.description.abstractEver since Dr. Harald zur Hausen won the noble prize in medicine in 2008 for discovering human papilloma virus (HPV) as the etiological factor for cervical cancer, the research has been robust in this field. More recent data from case–control studies and systematic review indicate that HPV is an independent risk factor for oral and oropharyngeal carcinomas. Oral squamous cell carcinoma (OSCC) represents 90% of all malignant tumours that affect the oral cavity. The most known viral cytopathic effect is koilocytosis, considered to be a major characteristic of HPV infection. Koilocytes are epithelial cells characterised by perinuclear haloes surrounding condensed nuclei and is accepted as pathognomonic (characteristic of a particular disease) of HPV infection. Aim The aim of this study was to verify the prevalence of koilocytes in OSCCs. Methodology A retrospective analysis was conducted on 60 paraffin-embedded tissue specimens that were obtained from patients with a histopathological diagnosis of OSCC. Haematoxylin and eosin-stained slides were submitted to examine under light microscopy, specifically for the determination of the presence of koilocytes and were analysed. Conclusion The results suggest that the presence of koilocytes is reliable for the detection of HPV presence in routine histopathology in OSCCs.en_US
dc.identifier.affiliationsProfessor, Department of Oral Pathology, VS Dental College and Hospital, K.R. Road, V.V. Puram, Bengaluru-560004, Karnataka, Indiaen_US
dc.identifier.affiliationsPrincipal & Professor (Director), Sri Rajiv Gandhi College of Dental Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsProfessor and head, Department of Oral Pathology, Dental Care and Research Centre, Sri Rajiv Gandhi College of Dental Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.citationSmitha T., Mohan C.V., Hemavathy S.. Study of Prevalence of Koilocytes in Oral Squamous Cell Carcinoma. Indian Journal of Mednodent and Allied Sciences. 2016 Jun; 4(2): 64-70en_US
dc.identifier.issn2347-6192
dc.identifier.issn2347-6206
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186056
dc.languageenen_US
dc.publisherAssociation of Medical Dental and Allied Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume4en_US
dc.source.urihttps://dx.doi.org/10.5958/2347-6206.2016.00010.8en_US
dc.subjectOral squamous cell carcinomaen_US
dc.subjectOral canceren_US
dc.subjectHPVen_US
dc.subjectDNAVirusen_US
dc.subjectOral carcinogenesisen_US
dc.titleStudy of Prevalence of Koilocytes in Oral Squamous Cell Carcinomaen_US
dc.typeJournal Articleen_US
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