A Comparative Evaluation of Losartan/ Hydrochlorothiazide (Fixed Combination) versus Amlodipine Monotherapy on Left Ventricular Hypertrophy, Biochemical Parameters and Adverse Effects in Patients of Hypertension.
| dc.contributor.author | Shaifali, Iram | |
| dc.contributor.author | Kapoor, A K | |
| dc.contributor.author | Singh, H K | |
| dc.date.accessioned | 2017-02-03T09:08:24Z | |
| dc.date.available | 2017-02-03T09:08:24Z | |
| dc.date.issued | 2014-02 | |
| dc.description.abstract | Background: Long-term administration of antihypertensives require better efficacy and tolerability. Moreover, the agent should regress left ventricular hypertrophy (LVH), which is an important predictor of cardiovascular events. Aims: To comparatively evaluate the effects of losartan/hydrochlorothiazide (LST/HCTZ) and amlodipine (AMLO) on LVH, biochemical parameters and adverse effects in hypertension. Material and methods: Two hundred fifty newly diagnosed hypertensive patients were randomly divided into two groups. LST 50 mg/HCTZ 12.5 mg and AMLO 5 mg once-daily, were administered. Biochemical parameters, adverse effects and ECG were recorded initially and after 6 months of therapy. Statistical analysis was done. Results: Both regimens significantly reduced mean SBP and DBP in each of the six follow ups (p < 0.001). LST/HCTZ caused regression of LVH in greater number of cases (26) than AMLO (20) and also showed a significant increase in mean values of serum creatinine, serum uric acid and high-density lipoprotein (HDL) levels and a significant decrease in Serum cholesterol. In AMLO group only serum creatinine was raised. The most common adverse effects in LST/HCTZ was dizziness (4.5%) and in AMLO group pedal edema (22%). Conclusion: Comparatively LST/HCTZ therapy causes regression of LVH in larger number of cases, increases HDL and is better tolerated. | en_US |
| dc.identifier.citation | Shaifali Iram, Kapoor A K, Singh H K. A Comparative Evaluation of Losartan/ Hydrochlorothiazide (Fixed Combination) versus Amlodipine Monotherapy on Left Ventricular Hypertrophy, Biochemical Parameters and Adverse Effects in Patients of Hypertension. Indian Journal of Clinical Practice. 2014 Feb; 24(9): 823-829. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/182953 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://medind.nic.in/iaa/t14/i2/iaat14i2p823.pdf | en_US |
| dc.subject | Losartan | en_US |
| dc.subject | hydrochlorothiazide | en_US |
| dc.subject | amlodipine | en_US |
| dc.subject | hypertension | en_US |
| dc.subject | left ventricular hypertrophy | en_US |
| dc.title | A Comparative Evaluation of Losartan/ Hydrochlorothiazide (Fixed Combination) versus Amlodipine Monotherapy on Left Ventricular Hypertrophy, Biochemical Parameters and Adverse Effects in Patients of Hypertension. | en_US |
| dc.type | Article | en_US |