Drug Release and Pharmacokinetics Behavior of a Simple Ethylcellulose Coating Pulsatile Tablet of Time-controlled Explosive System

dc.contributor.authorYang, Mohuien_US
dc.contributor.authorXingli Wangen_US
dc.contributor.authorJiabi Ouyangen_US
dc.contributor.authorZhen Zhangen_US
dc.contributor.authorTan, Yanien_US
dc.contributor.authorLi, Shaen_US
dc.date.accessioned2020-11-18T10:29:11Z
dc.date.available2020-11-18T10:29:11Z
dc.date.issued2020-03
dc.description.abstractBackground The time rhythm of human body is associated with the occurrence and development of manydiseases. Kinds of diseases of particular onset biorhythm provided the room for the development ofchronopharmacological drug delivery systems.Aim In this work, the drug release and pharmacokinetics behavior of metoprolol tartrate (MT) pulsatile tabletdeveloped in our lab was investigated to figure out its feasibility of convenient drug taking to exert effectivechronotherapy for cardiovascular diseases like hypertension and angina pectoris.Methods The in vitro release behavior of MT pulsatile tablets was investigated by using basket method. Theappearance and morphology of MT pulsatile tablets during drug release was observed by naked eye and scanning electronic microscope, respectively. In vivo pharmacokinetics performance was studied in NewZealand rabbits.Results The lag time of MT pulsatile tablets was approximately 7 h in vitro, and a fast release was observedthereafter, with more than 90% releasing within 10 min. The pharmacokinetics study in rabbits demonstrateda perfect consistence in the absorption lag time of 7.04 ± 0.29 h in vivo. Compared with the marketedconventional tablet, the MT pulsatile tablet showed a bioequivalence in absorption extent with a relativebioavailability of 110.04%, but not in absorption rate.Conclusion The designed lag time of 7 hours enabled the MT pulsatile tablets to achieve effectivechronotherapy for cardiovascular diseases like hypertension and angina pectoris with a high attack rhythmaround 4:00-6:00 A.M by giving medicine conveniently around 22:00 P.M. the night before.en_US
dc.identifier.affiliationsCollege of Pharmacy, Jinan University, Guangzhou, Chinaen_US
dc.identifier.affiliationsShenzhen Polytechnic, Shenzhen, Chinaen_US
dc.identifier.affiliationsInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drugen_US
dc.identifier.affiliationsDevelopment of Chinese Ministry of Education, College of Pharmacy, Jinan University, Guangzhou, Chinaen_US
dc.identifier.affiliationsGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou, Chinaen_US
dc.identifier.citationYang Mohui, Xingli Wang, Jiabi Ouyang, Zhen Zhang, Tan Yani, Li Sha. Drug Release and Pharmacokinetics Behavior of a Simple Ethylcellulose Coating Pulsatile Tablet of Time-controlled Explosive System. Journal of Pharmaceutical and Biomedical Sciences. 2020 Mar; 10(3): 58-64en_US
dc.identifier.issn2230-7885
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215711
dc.languageenen_US
dc.publisherLawarence Press Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume10en_US
dc.source.urihttps://lawarencepress.com/ojs/index.php/JPBMS/article/view/607/pdf_290en_US
dc.subjectPulsatile tablets; Metoprolol tartrate; Drug release; Pharmacokinetics; Bioequivalence.en_US
dc.titleDrug Release and Pharmacokinetics Behavior of a Simple Ethylcellulose Coating Pulsatile Tablet of Time-controlled Explosive Systemen_US
dc.typeJournal Articleen_US
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