Final Health and Environmental Risk Assessment of Genetically Modified Cotton GHB614

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dc.contributor.authorAndreassen, Åshilden_US
dc.contributor.authorBakke, Anne Marieen_US
dc.contributor.authorJunttila, Olavien_US
dc.contributor.authorMikalsen, Arneen_US
dc.contributor.authorSipinen, Ville Erlingen_US
dc.contributor.authorVikse, Roseen_US
dc.contributor.authorBrandtzæg, Peren_US
dc.contributor.authorDalen, Knut Helkåsen_US
dc.contributor.authorDalen, Knut Tomasen_US
dc.contributor.authorMeadow, Richarden_US
dc.contributor.authorMåren, Inger Elisabethen_US
dc.contributor.authorNielsen, Kåre M.en_US
dc.contributor.authorSanden, Monicaen_US
dc.contributor.authorOpsahl-Sorteberg, Hilde-Gunnen_US
dc.date.accessioned2020-01-02T06:15:30Z
dc.date.available2020-01-02T06:15:30Z
dc.date.issued2018-05
dc.description.abstractGenetically modified cotton GHB614 from Bayer Crop Science expresses a modified epsps gene (2mepsps) gene from maize encoding the enzyme 5-enolpyruvylshikimate 3-phosphate synthase (2 mEPSPS), which confers tolerance to the herbicide glyphosate. Updated bioinformatics analyses of the inserted DNA and flanking sequences in GHB614 have not indicated potential production of putatively harmful toxins or allergens caused by the genetic modification. Genomic stability of the functional insert and consistent expression of the 2mepsps gene has been shown over several generations of cotton GHB614. Field trials indicate that with the exception of the introduced trait, cotton GHB614 is compositionally, phenotypically and agronomically equivalent to its conventional counterpart Coker 312 and other cotton cultivars. A 42-day nutritional assessment trial with broilers did not reveal adverse effects of cottonseed meal from GHB614. The 2mEPSPS protein produced in GHB614 does not show amino acid sequence resemblance to known toxins or IgE-dependent allergens, nor has it been reported to cause IgE-mediated allergic reactions. It is therefore unlikely that the 2 mEPSPS protein will cause toxic or IgE-mediated allergic reactions to food or feed containing cotton GHB614 compared to conventional cotton cultivars. Cotton is not cultivated in Norway, and there are no cross-compatible wild or weedy relatives of cotton in Europe. Based on current knowledge and with the exception of the introduced trait, the VKM GMO Panel concludes that cotton GHB614 is nutritionally, compositionally, phenotypically and agronomically equivalent to and as safe as its conventional counterpart and other cotton cultivars. Considering the intended uses, which exclude cultivation, the VKM GMO Panel concludes that GHB614 does not represent an environmental risk in Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian Institute of Public Health (FHI), Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian Institute of Public Health (FHI), Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), University of Oslo, Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian University of Life Sciences, Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), University of Bergen, Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Institute of Marine Research, Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Institute of Marine Research, Norway.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Oslo and Akershus University College of Applied Sciences, Norway.en_US
dc.identifier.citationAndreassen Åshild, Bakke Anne Marie, Junttila Olavi, Mikalsen Arne, Sipinen Ville Erling, Vikse Rose, Brandtzæg Per, Dalen Knut Helkås, Dalen Knut Tomas, Meadow Richard, Måren Inger Elisabeth, Nielsen Kåre M., Sanden Monica, Opsahl-Sorteberg Hilde-Gunn . Final Health and Environmental Risk Assessment of Genetically Modified Cotton GHB614. European Journal of Nutrition and Food Safety. 2018 May; 8(3): 119-120en_US
dc.identifier.issn2347-5641
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189534
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber3en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.9734/EJNFS/2018/42108en_US
dc.subjectVKMen_US
dc.subject(benefit and) risk assessmenten_US
dc.subjectNorwegian Scientific Committee for Food Safetyen_US
dc.subjectNorwegian Food Safety Authority/Norwegian Environment Agencyen_US
dc.subjectGMOen_US
dc.subjectcotton (Gossypium hirsutum L)en_US
dc.subjectEFSA/GMO/NL/2008/51en_US
dc.subjectgenetically modified cotton GHB14en_US
dc.subjectunique identifier BCS-GHØØ2-5en_US
dc.subjectherbicide glyphosateen_US
dc.subjectglyphosate tolerant 2mEPSPS proteinen_US
dc.subject2mepsps geneen_US
dc.subjectfood/feed safetyen_US
dc.subjecthuman and animal healthen_US
dc.subjectimport and processingen_US
dc.subjectRegulation (EC) No 1829/2003en_US
dc.titleFinal Health and Environmental Risk Assessment of Genetically Modified Cotton GHB614en_US
dc.typeJournal Articleen_US
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