Antibody Response to SARS-COV-2 Vaccination in Healthcare Workers of Uttarakhand: A Prospective Follow-up Study

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dc.contributor.authorMittal, Gen_US
dc.contributor.authorSingh, Ren_US
dc.contributor.authorMittal, Men_US
dc.contributor.authorJahoor, Sen_US
dc.contributor.authorBisht, Pen_US
dc.contributor.authorKakati, B.en_US
dc.date.accessioned2023-08-09T06:12:07Z
dc.date.available2023-08-09T06:12:07Z
dc.date.issued2023-03
dc.description.abstractBackground: Countries around the world are now racing to vaccinate people against SARS-CoV-2, the virus that causes COVID-19. The Government of India also rolled out its vaccination drive from 16th January ‘2021. Aims: To estimate the antibody response of the COVID-19 vaccine in the form of SARS-COV-2 IgG antibodies in vaccinated healthcare workers. Methods: Prospective follow-up was study conducted on healthcare workers (HCWs) of a Medical college in Dehradun, Uttarakhand. Healthcare workers who have been vaccinated for COVID-19 were tested for SARS-CoV-2-IgG antibodies at regular intervals i.e at 4 weeks after the 1st dose and then again at 4 weeks after the 2nd dose. The third sample was taken 6 months after the 2nd dose. Results: A total of 302 HCWs were enrolled in the study who gave their samples for IgG antibody estimation after the Covishield vaccine. After 4 weeks of completion of both doses, 96% HCWs formed SARS-COV-2 IgG antibodies, whereas 4% didn’t. Then after 6 months of follow-up, 14% HCWs have become negative for antibodies and better immunity is seen in people who also got infected with COVID-19 during this time. Conclusion: This study concludes that the immunity gained after vaccination is waning off in around 6 months and there is a need for a booster dose, especially for people at high risk. The infection control practices still play a crucial role in the prevention of this deadly disease.en_US
dc.identifier.affiliationsDepartment of Microbiology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, Indiaen_US
dc.identifier.affiliationsDepartment of Neurology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, Indiaen_US
dc.identifier.affiliationsDepartment of Infection Control, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, Indiaen_US
dc.identifier.citationMittal G, Singh R, Mittal M, Jahoor S, Bisht P, Kakati B.. Antibody Response to SARS-COV-2 Vaccination in Healthcare Workers of Uttarakhand: A Prospective Follow-up Study. Indian Journal of Community Health. 2023 Mar; 35(1): 99 – 102en_US
dc.identifier.issn0971-7587
dc.identifier.issn2248-9509
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222011
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume35en_US
dc.source.urihttps://doi.org/10.47203/IJCH.2023.v35i01.018en_US
dc.subjectHumansen_US
dc.subjectCOVID-19 Vaccinesen_US
dc.subjectImmunoglobulin Gen_US
dc.subjectSARS-CoV-2en_US
dc.subjectChAdOx1 nCoV-19en_US
dc.subjectFollow-Up Studiesen_US
dc.subjectCOVID-19en_US
dc.subjectProspective Studiesen_US
dc.subjectAntibodiesen_US
dc.subjectViral vaccinationen_US
dc.subjectVaccinesen_US
dc.subjectGovernmenten_US
dc.titleAntibody Response to SARS-COV-2 Vaccination in Healthcare Workers of Uttarakhand: A Prospective Follow-up Studyen_US
dc.typeJournal Articleen_US
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