Clinico-pathological predictive factors of response to interferon therapy in chronic hepatitis C.

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dc.contributor.authorThavarungkul, Pen_US
dc.contributor.authorToriyama, Ken_US
dc.contributor.authorKusuda, Men_US
dc.contributor.authorKamito, Hen_US
dc.contributor.authorKamito, Men_US
dc.contributor.authorNakayama, Ten_US
dc.contributor.authorKato, Yen_US
dc.contributor.authorItakura, Hen_US
dc.date.accessioned2009-05-27T14:57:06Z
dc.date.available2009-05-27T14:57:06Z
dc.date.issued1996-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractWe performed a clinico-pathological study to determine which pre-treatment factors could predict the response to interferon (IFN) therapy in 55 Japanese patients with chronic hepatitis C. Responses to the IFN therapy were evaluated as sustained response, relapse and non-response by the presence or absence of serum hepatitis C virus (HCV) RNA during the course of treatment and at least 6-months post-treatment. The numbers of sustained response, relapse and non-response were 16 (29.0%), 25 (45.5%) and 14 (25.5%), respectively. Eight out of 16 sustained response cases (50%) showed HCV genotype III. Eight among 10 patients with HCV genotype III (80%) were sustained responders. HCV genotypes were found to be correlated with the response to the IFN therapy (p < 0.0001). None of the histological features, the types of the IFN therapy and other clinical factors showed significant differences. These findings suggest that outcome of the IFN therapy in chronic hepatitis C can be predicted by a virological factor, and that HCV genotype III is a useful predictor of a favorable outcome.en_US
dc.description.affiliationDepartment of Medical Services, Rajvithi Hospital, Bangkok, Thailand.en_US
dc.identifier.citationThavarungkul P, Toriyama K, Kusuda M, Kamito H, Kamito M, Nakayama T, Kato Y, Itakura H. Clinico-pathological predictive factors of response to interferon therapy in chronic hepatitis C. The Southeast Asian Journal of Tropical Medicine and Public Health. 1996 Mar; 27(1): 85-90en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/31522
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshBiopsyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatitis B virus --geneticsen_US
dc.subject.meshHepatitis C --pathologyen_US
dc.subject.meshHepatitis, Chronic --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Subcutaneousen_US
dc.subject.meshInterferon Alfa-2a --therapeutic useen_US
dc.subject.meshInterferon Alfa-2b --therapeutic useen_US
dc.subject.meshInterferon-alpha --therapeutic useen_US
dc.subject.meshJapanen_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshRNA, Viral --blooden_US
dc.titleClinico-pathological predictive factors of response to interferon therapy in chronic hepatitis C.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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